Animal Models for Depression Associated with HIV-1 Infection

Antiretroviral therapy has greatly extended the lifespan of people living with human immunodeficiency virus (PLHIV). As a result, the long-term effects of HIV infection, in particular those originating in the central nervous system (CNS), such as HIV associated depression, have gained importance. An...

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Bibliographic Details
Published in:Journal of neuroimmune pharmacology 2014-03, Vol.9 (2), p.195-208
Main Authors: Barreto, Isabella Cristina Gomes, Viegas, Patricia, Ziff, Edward B., Konkiewitz, Elisabete Castelon
Format: Article
Language:English
Subjects:
AIDS Dementia Complex - psychology
Animals
Animals, Genetically Modified
Antiretroviral drugs
Biomedical and Life Sciences
Biomedicine
Cell Biology
Depression - virology
Disease Models, Animal
HIV
HIV-1
Human immunodeficiency virus
Human immunodeficiency virus 1
Immunology
Infections
Invited Review
Neurosciences
Pharmacology/Toxicology
Virology
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Summary:Antiretroviral therapy has greatly extended the lifespan of people living with human immunodeficiency virus (PLHIV). As a result, the long-term effects of HIV infection, in particular those originating in the central nervous system (CNS), such as HIV associated depression, have gained importance. Animal models for HIV infection have proved very useful for understanding the disease and developing treatment strategies. However, HIV associated depression remains poorly understood and so far there is neither a fully satisfactory animal model, nor a pathophysiologically guided treatment for this condition. Here we review the neuroimmunological, neuroendocrine, neurotoxic and neurodegenerative basis for HIV depression and discuss strategies for employing HIV animal models, in particular humanized mice which are susceptible to HIV infection, for the study of HIV depression.
ISSN:1557-1890
1557-1904
DOI:10.1007/s11481-013-9518-9