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Quantitative transmission characteristics of different H5 low pathogenic avian influenza viruses in Muscovy ducks
EU annual serosurveillance programs show that domestic duck flocks have the highest seroprevalence of H5 antibodies, demonstrating the circulation of notifiable avian influenza virus (AIV) according to OIE, likely low pathogenic (LP). Therefore, transmission characteristics of LPAIV within these flo...
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Published in: | Veterinary microbiology 2014-01, Vol.168 (1), p.78-87 |
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creator | Niqueux, Éric Picault, Jean-Paul Amelot, Michel Allée, Chantal Lamandé, Josiane Guillemoto, Carole Pierre, Isabelle Massin, Pascale Blot, Guillaume Briand, François-Xavier Rose, Nicolas Jestin, Véronique |
description | EU annual serosurveillance programs show that domestic duck flocks have the highest seroprevalence of H5 antibodies, demonstrating the circulation of notifiable avian influenza virus (AIV) according to OIE, likely low pathogenic (LP). Therefore, transmission characteristics of LPAIV within these flocks can help to understand virus circulation and possible risk of propagation. This study aimed at estimating transmission parameters of four H5 LPAIV (three field strains from French poultry and decoy ducks, and one clonal reverse-genetics strain derived from one of the former), using a SIR model to analyze data from experimental infections in SPF Muscovy ducks. The design was set up to accommodate rearing on wood shavings with a low density of 1.6ducks/m2: 10 inoculated ducks were housed together with 15 contact-exposed ducks. Infection was monitored by RNA detection on oropharyngeal and cloacal swabs using real-time RT-PCR with a cutoff corresponding to 2–7 EID50. Depending on the strain, the basic reproduction number (R0) varied from 5.5 to 42.7, confirming LPAIV could easily be transmitted to susceptible Muscovy ducks. The lowest R0 estimate was obtained for a H5N3 field strain, due to lower values of transmission rate and duration of infectious period, whereas reverse-genetics derived H5N1 strain had the highest R0. Frequency and intensity of clinical signs were also variable between strains, but apparently not associated with longer infectious periods. Further comparisons of quantitative transmission parameters may help to identify relevant viral genetic markers for early detection of potentially more virulent strains during surveillance of LPAIV. |
doi_str_mv | 10.1016/j.vetmic.2013.10.020 |
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Therefore, transmission characteristics of LPAIV within these flocks can help to understand virus circulation and possible risk of propagation. This study aimed at estimating transmission parameters of four H5 LPAIV (three field strains from French poultry and decoy ducks, and one clonal reverse-genetics strain derived from one of the former), using a SIR model to analyze data from experimental infections in SPF Muscovy ducks. The design was set up to accommodate rearing on wood shavings with a low density of 1.6ducks/m2: 10 inoculated ducks were housed together with 15 contact-exposed ducks. Infection was monitored by RNA detection on oropharyngeal and cloacal swabs using real-time RT-PCR with a cutoff corresponding to 2–7 EID50. Depending on the strain, the basic reproduction number (R0) varied from 5.5 to 42.7, confirming LPAIV could easily be transmitted to susceptible Muscovy ducks. The lowest R0 estimate was obtained for a H5N3 field strain, due to lower values of transmission rate and duration of infectious period, whereas reverse-genetics derived H5N1 strain had the highest R0. Frequency and intensity of clinical signs were also variable between strains, but apparently not associated with longer infectious periods. Further comparisons of quantitative transmission parameters may help to identify relevant viral genetic markers for early detection of potentially more virulent strains during surveillance of LPAIV.</description><identifier>ISSN: 0378-1135</identifier><identifier>EISSN: 1873-2542</identifier><identifier>DOI: 10.1016/j.vetmic.2013.10.020</identifier><identifier>PMID: 24287046</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Avian influenza virus ; Basic reproduction number (R0) ; Ducks - virology ; Horizontal transmission ; Influenza A virus - pathogenicity ; Influenza A virus - physiology ; Influenza in Birds - pathology ; Influenza in Birds - transmission ; Influenza in Birds - virology ; Low pathogenic avian influenza ; Muscovy ducks ; Reverse Transcriptase Polymerase Chain Reaction ; Specific Pathogen-Free Organisms</subject><ispartof>Veterinary microbiology, 2014-01, Vol.168 (1), p.78-87</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. 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Therefore, transmission characteristics of LPAIV within these flocks can help to understand virus circulation and possible risk of propagation. This study aimed at estimating transmission parameters of four H5 LPAIV (three field strains from French poultry and decoy ducks, and one clonal reverse-genetics strain derived from one of the former), using a SIR model to analyze data from experimental infections in SPF Muscovy ducks. The design was set up to accommodate rearing on wood shavings with a low density of 1.6ducks/m2: 10 inoculated ducks were housed together with 15 contact-exposed ducks. Infection was monitored by RNA detection on oropharyngeal and cloacal swabs using real-time RT-PCR with a cutoff corresponding to 2–7 EID50. Depending on the strain, the basic reproduction number (R0) varied from 5.5 to 42.7, confirming LPAIV could easily be transmitted to susceptible Muscovy ducks. The lowest R0 estimate was obtained for a H5N3 field strain, due to lower values of transmission rate and duration of infectious period, whereas reverse-genetics derived H5N1 strain had the highest R0. Frequency and intensity of clinical signs were also variable between strains, but apparently not associated with longer infectious periods. Further comparisons of quantitative transmission parameters may help to identify relevant viral genetic markers for early detection of potentially more virulent strains during surveillance of LPAIV.</description><subject>Animals</subject><subject>Avian influenza virus</subject><subject>Basic reproduction number (R0)</subject><subject>Ducks - virology</subject><subject>Horizontal transmission</subject><subject>Influenza A virus - pathogenicity</subject><subject>Influenza A virus - physiology</subject><subject>Influenza in Birds - pathology</subject><subject>Influenza in Birds - transmission</subject><subject>Influenza in Birds - virology</subject><subject>Low pathogenic avian influenza</subject><subject>Muscovy ducks</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Specific Pathogen-Free Organisms</subject><issn>0378-1135</issn><issn>1873-2542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkU1rVDEUhoNY7LT6D0SydHPHfN6PjSCl2kKLFHQdziTn2ox3kmmSe6X-ejNMdWlXgTfPm8PJQ8hbztac8fbDdr1g2Xm7FozLGq2ZYC_IivedbIRW4iVZMdn1DedSn5KznLeMMTW07BU5FUr0HVPtijzczRCKL1D8grQkCHnnc_YxUHsPCWzB5HPxNtM4UufHEROGQq80neIvuodyH39g8JbC4iFQH8ZpxvAb6OLTnDHXhN7O2cblkbrZ_syvyckIU8Y3T-c5-f758tvFVXPz9cv1xaebxspBl6YFPYAA4eqyygFoVNApJ-TIXT9snOxZazuUm02nmbModKd7qHfa1ZqV8py8P767T_FhxlxMXcziNEHAOGfDtWCyb9uBPY-qgXW9VFpXVB1Rm2LOCUezT34H6dFwZg5ezNYcvZiDl0NavdTau6cJ82aH7l_pr4gKfDwCWL9k8ZhMth6DRecT2mJc9P-f8AfV9KLe</recordid><startdate>20140110</startdate><enddate>20140110</enddate><creator>Niqueux, Éric</creator><creator>Picault, Jean-Paul</creator><creator>Amelot, Michel</creator><creator>Allée, Chantal</creator><creator>Lamandé, Josiane</creator><creator>Guillemoto, Carole</creator><creator>Pierre, Isabelle</creator><creator>Massin, Pascale</creator><creator>Blot, Guillaume</creator><creator>Briand, François-Xavier</creator><creator>Rose, Nicolas</creator><creator>Jestin, Véronique</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>20140110</creationdate><title>Quantitative transmission characteristics of different H5 low pathogenic avian influenza viruses in Muscovy ducks</title><author>Niqueux, Éric ; 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The lowest R0 estimate was obtained for a H5N3 field strain, due to lower values of transmission rate and duration of infectious period, whereas reverse-genetics derived H5N1 strain had the highest R0. Frequency and intensity of clinical signs were also variable between strains, but apparently not associated with longer infectious periods. Further comparisons of quantitative transmission parameters may help to identify relevant viral genetic markers for early detection of potentially more virulent strains during surveillance of LPAIV.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24287046</pmid><doi>10.1016/j.vetmic.2013.10.020</doi><tpages>10</tpages></addata></record> |
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subjects | Animals Avian influenza virus Basic reproduction number (R0) Ducks - virology Horizontal transmission Influenza A virus - pathogenicity Influenza A virus - physiology Influenza in Birds - pathology Influenza in Birds - transmission Influenza in Birds - virology Low pathogenic avian influenza Muscovy ducks Reverse Transcriptase Polymerase Chain Reaction Specific Pathogen-Free Organisms |
title | Quantitative transmission characteristics of different H5 low pathogenic avian influenza viruses in Muscovy ducks |
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