Lower limb joints kinematics in essential tremor and the effect of thalamic stimulation

Highlights ► Thalamic deep brain stimulation modulates the cerebello-thalamo-cortical pathway. ► Joint kinematics of lower limbs are impaired in advanced cases of Essential Tremor. ► Chronic thalamic stimulation normalized this highly variable joints excursion. ► Supratherapeutic thalamic stimulatio...

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Bibliographic Details
Published in:Gait & posture 2012-06, Vol.36 (2), p.187-193
Main Authors: Fasano, Alfonso, Herzog, Jan, Raethjen, Jan, Rose, Franziska E.M, Volkmann, Jens, Falk, Daniela, Deuschl, Günther
Format: Article
Language:English
Subjects:
Aged
Ankle Joint - physiopathology
Biomechanical Phenomena
Cerebellum
Deep Brain Stimulation
Deep drain stimulation
Essential tremor
Essential Tremor - complications
Essential Tremor - therapy
Female
Gait
Gait Ataxia - complications
Gait Ataxia - physiopathology
Gait Ataxia - therapy
Hip Joint - physiopathology
Humans
Kinematics
Knee Joint - physiopathology
Male
Middle Aged
Orthopedics
Range of Motion, Articular
Thalamus
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Summary:Highlights ► Thalamic deep brain stimulation modulates the cerebello-thalamo-cortical pathway. ► Joint kinematics of lower limbs are impaired in advanced cases of Essential Tremor. ► Chronic thalamic stimulation normalized this highly variable joints excursion. ► Supratherapeutic thalamic stimulation induces ataxic changes of joint excursion. ► The beneficial effect on ataxic symptoms is limited to a narrow therapeutic window.
ISSN:0966-6362
1879-2219
DOI:10.1016/j.gaitpost.2012.02.013