cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists

The NPY5 receptor binding and pharmacokinetic properties of a novel series of cis-1-oxo-heterocyclyl-4-amido-cyclohexane derivatives are described.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2014-03, Vol.24 (6), p.1458-1461
Main Authors: Burns, James Ford, Chen, Bin, Chen, Chien-An, Doller, Dario, Edelmenky, Eman, Jiang, Yu, Peterson, John M., Sabio, Michael, Weiss, Jessie, White, Andrew D., Wu, Lingyun, Bhardwaj, Rajinder, Chandrasena, Gamini, Boyle, Noel J., Huang, Xinyan
Format: Article
Language:English
Subjects:
Animals
Cyclohexanes - chemical synthesis
Cyclohexanes - chemistry
Cyclohexanes - pharmacokinetics
Half-Life
Humans
Isomerism
Mice
Microsomes, Liver - metabolism
Neuropeptide Y5 receptor antagonist
Receptors, Neuropeptide Y - antagonists & inhibitors
Receptors, Neuropeptide Y - metabolism
Structure-Activity Relationship
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Description
Summary:The NPY5 receptor binding and pharmacokinetic properties of a novel series of cis-1-oxo-heterocyclyl-4-amido-cyclohexane derivatives are described.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2014.02.023