Fluorescent nitric oxide detection using cobalt substituted myoglobin

We report two advances in optical biosensing of nitric oxide (NO). Firstly, we developed an improved biomolecular gated system for fluorescent transduction of heme-NO binding. Secondly, through a cobalt substitution, the detection limit for NO was decreased an order of magnitude lower than that of n...

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Bibliographic Details
Published in:RSC advances 2014-01, Vol.4 (20), p.10269-10272
Main Authors: Rapson, Trevor D., Dacres, Helen, Trowell, Stephen C.
Format: Article
Language:English
Subjects:
Binding
Cobalt
Myoglobin
Nitric oxide
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Summary:We report two advances in optical biosensing of nitric oxide (NO). Firstly, we developed an improved biomolecular gated system for fluorescent transduction of heme-NO binding. Secondly, through a cobalt substitution, the detection limit for NO was decreased an order of magnitude lower than that of native myoglobin.
ISSN:2046-2069
2046-2069
DOI:10.1039/c3ra47658h