Polymer-Assisted Hydrothermal Synthesis of Hierarchically Arranged Hydroxyapatite Nanoceramic

Flower-like hydroxyapatite (HA) nanostructures were synthesized by a polymer-assisted hydrothermal method. The thickness of the petals/plates decreased from 200 nm to 40 nm as the polymer concentration increased. The thickness also decreased as the hydrothermal treatment time increased from 6 to 12...

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Bibliographic Details
Published in:Journal of nanomaterials 2013-01, Vol.2013 (2013), p.1-8
Main Authors: Nathanael, A. Joseph, Oh, Tae Hwan, Han, Sung Soo
Format: Article
Language:English
Subjects:
Biocompatibility
Biological activity
Biomedical research
Bone cancer
Cell growth
Crystal structure
Crystallinity
Drug delivery systems
Hydroxyapatite
Microscopy
Nanocrystals
Nanomaterials
Nanoparticles
Nanostructure
Nitrates
Petals
Positioning
Synthesis
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Summary:Flower-like hydroxyapatite (HA) nanostructures were synthesized by a polymer-assisted hydrothermal method. The thickness of the petals/plates decreased from 200 nm to 40 nm as the polymer concentration increased. The thickness also decreased as the hydrothermal treatment time increased from 6 to 12 hr. The HRTEM and SAED patterns suggest that the floral-like HA nanostructures are single crystalline in nature. Structural analysis based on XRD and Raman experiments implied that the produced nanostructure is a pure form of HA without any other impurities. The possible formation mechanism was discussed for the formation of flower-like HA nanostructures during polymer-assisted hydrothermal synthesis. Finally, in vitro cellular analysis revealed that the hierarchically arranged HA nanoceramic had improved cell viability relative to other structures. The cells were actively proliferated over these nanostructures due to lower cytotoxicity. Overall, the size and the crystallinity of the nanostructures played a role in improving the cell proliferation.
ISSN:1687-4110
1687-4129
DOI:10.1155/2013/962026