Study to Eliminate the Effect of Hyperbilirubinemia in Measurement of Blood Coagulation Assay

In this paper, a low cost coagulation analyzer is developed using an LPC 2138 Microcontroller to determine the values of PT (Prothrombin Time) and APTT (Activated partial Thomboplastin Time) in samples with Hyperbilirubinimea (High Bilirubin) ranging from 0-22.0 mg/dl. Most of the conventional Instr...

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Bibliographic Details
Published in:Sensors & transducers 2013-02, Vol.149 (2), p.187-187
Main Authors: Raghunathan, R, Neelamegam, P, Jamaludeen, A, Murugananthan, K
Format: Article
Language:English
Subjects:
Analyzers
Blood
Blood coagulation
Clotting
Law
Light-emitting diodes
Liver cirrhosis
Prothrombin
Transducers
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Summary:In this paper, a low cost coagulation analyzer is developed using an LPC 2138 Microcontroller to determine the values of PT (Prothrombin Time) and APTT (Activated partial Thomboplastin Time) in samples with Hyperbilirubinimea (High Bilirubin) ranging from 0-22.0 mg/dl. Most of the conventional Instruments are able to detect the clotting time only when the bilirubin level in the sample is within the range of 0-5.0 mg/dl. In the developed instrument yellow light (LED 590 nm) having a minimum absorbance (Beer-Lambert's Law) while passing through the yellowish sample is used to detect the changes in light intensity while clotting of the sample occurs and thus eliminates the interference of higher bilirubin content (above 4 mg/dl) in blood samples. It is observed that the designed Instrument shows the performance of measurement of PT and APTT in 95.5% samples with hyperbilirubinemia against 31.8% of samples in COAT-1 analyzer.
ISSN:2306-8515
1726-5479
1726-5479