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Variation in the Transmission Near-Infrared Signal with Depth in Turbid Media
Transmission near-infrared (NIR) measurements of a 1 mm thick aspirin disk were made at different positions as it was moved through a stack of eight 0.5 mm thick disks of microcrystalline cellulose (Avicel). The magnitude of the first derivative of absorbance for the aspirin interlayer at 8934 cm−1...
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Published in: | Applied spectroscopy 2014-03, Vol.68 (3), p.383-387 |
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container_title | Applied spectroscopy |
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creator | Kellichan, Nicola Nordon, Alison Matousek, Pavel Littlejohn, David McGeorge, Gary |
description | Transmission near-infrared (NIR) measurements of a 1 mm thick aspirin disk were made at different positions as it was moved through a stack of eight 0.5 mm thick disks of microcrystalline cellulose (Avicel). The magnitude of the first derivative of absorbance for the aspirin interlayer at 8934 cm−1 was lower when the disk was placed at the top or bottom of the stack of Avicel disks, with the largest signal observed when the aspirin was positioned at the central positions. The variation in signal with depth is consistent with that observed previously for transmission Raman spectrometry. In both cases, the trend observed can be attributed to lower photon density at the air-sample interface, relative to the center of the sample, owing to loss of photons to the air. This results in a reduction in the number of photons absorbed or Raman photons generated and subsequently detected when the interlayer occupies a near-surface position. |
doi_str_mv | 10.1366/13-07002 |
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The magnitude of the first derivative of absorbance for the aspirin interlayer at 8934 cm−1 was lower when the disk was placed at the top or bottom of the stack of Avicel disks, with the largest signal observed when the aspirin was positioned at the central positions. The variation in signal with depth is consistent with that observed previously for transmission Raman spectrometry. In both cases, the trend observed can be attributed to lower photon density at the air-sample interface, relative to the center of the sample, owing to loss of photons to the air. This results in a reduction in the number of photons absorbed or Raman photons generated and subsequently detected when the interlayer occupies a near-surface position.</description><identifier>ISSN: 0003-7028</identifier><identifier>EISSN: 1943-3530</identifier><identifier>DOI: 10.1366/13-07002</identifier><identifier>PMID: 24666957</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Absorption ; Aspirin ; Cellulose ; Cellulose - chemistry ; Disks ; Dosage Forms ; Interlayers ; Models, Chemical ; Photons ; Spectrometry ; Spectroscopy ; Spectroscopy, Near-Infrared - methods ; Stacks</subject><ispartof>Applied spectroscopy, 2014-03, Vol.68 (3), p.383-387</ispartof><rights>2014 Society for Applied Spectroscopy</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-68a83439680bc745db30abd345492dbd448e4027284264fb832e372d20f11e993</citedby><cites>FETCH-LOGICAL-c380t-68a83439680bc745db30abd345492dbd448e4027284264fb832e372d20f11e993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24666957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kellichan, Nicola</creatorcontrib><creatorcontrib>Nordon, Alison</creatorcontrib><creatorcontrib>Matousek, Pavel</creatorcontrib><creatorcontrib>Littlejohn, David</creatorcontrib><creatorcontrib>McGeorge, Gary</creatorcontrib><title>Variation in the Transmission Near-Infrared Signal with Depth in Turbid Media</title><title>Applied spectroscopy</title><addtitle>Appl Spectrosc</addtitle><description>Transmission near-infrared (NIR) measurements of a 1 mm thick aspirin disk were made at different positions as it was moved through a stack of eight 0.5 mm thick disks of microcrystalline cellulose (Avicel). The magnitude of the first derivative of absorbance for the aspirin interlayer at 8934 cm−1 was lower when the disk was placed at the top or bottom of the stack of Avicel disks, with the largest signal observed when the aspirin was positioned at the central positions. The variation in signal with depth is consistent with that observed previously for transmission Raman spectrometry. In both cases, the trend observed can be attributed to lower photon density at the air-sample interface, relative to the center of the sample, owing to loss of photons to the air. This results in a reduction in the number of photons absorbed or Raman photons generated and subsequently detected when the interlayer occupies a near-surface position.</description><subject>Absorption</subject><subject>Aspirin</subject><subject>Cellulose</subject><subject>Cellulose - chemistry</subject><subject>Disks</subject><subject>Dosage Forms</subject><subject>Interlayers</subject><subject>Models, Chemical</subject><subject>Photons</subject><subject>Spectrometry</subject><subject>Spectroscopy</subject><subject>Spectroscopy, Near-Infrared - methods</subject><subject>Stacks</subject><issn>0003-7028</issn><issn>1943-3530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkD1PwzAQhi0EoqUg8QtQFiSWwPkz9ojKV6UWBgpr5MRO66pNip0I8e9xaYGBheVOd3ru1elB6BTDJaZCXGGaQgZA9lAfK0ZTyinsoz4A0DQDInvoKIRFHLmi_BD1CBNCKJ710eRVe6db19SJq5N2bpOp13VYuRA2u0erfTqqK6-9Ncmzm9V6mby7dp7c2HWs8Wba-cKZZGKN08fooNLLYE92fYBe7m6nw4d0_HQ_Gl6P05JKaFMhtaSMKiGhKDPGTUFBF4YyzhQxhWFMWgYkI5IRwapCUmJpRgyBCmOrFB2gi23u2jdvnQ1tHh8u7XKpa9t0IcecgBIcBP4HiiHDlAP7RUvfhOBtla-9W2n_kWPIN55jyb88R_Rsl9oVK2t-wG-xETjfAkHPbL5oOh_Nhb9Bn1vBf9g</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Kellichan, Nicola</creator><creator>Nordon, Alison</creator><creator>Matousek, Pavel</creator><creator>Littlejohn, David</creator><creator>McGeorge, Gary</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140301</creationdate><title>Variation in the Transmission Near-Infrared Signal with Depth in Turbid Media</title><author>Kellichan, Nicola ; Nordon, Alison ; Matousek, Pavel ; Littlejohn, David ; McGeorge, Gary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-68a83439680bc745db30abd345492dbd448e4027284264fb832e372d20f11e993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Absorption</topic><topic>Aspirin</topic><topic>Cellulose</topic><topic>Cellulose - chemistry</topic><topic>Disks</topic><topic>Dosage Forms</topic><topic>Interlayers</topic><topic>Models, Chemical</topic><topic>Photons</topic><topic>Spectrometry</topic><topic>Spectroscopy</topic><topic>Spectroscopy, Near-Infrared - methods</topic><topic>Stacks</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kellichan, Nicola</creatorcontrib><creatorcontrib>Nordon, Alison</creatorcontrib><creatorcontrib>Matousek, Pavel</creatorcontrib><creatorcontrib>Littlejohn, David</creatorcontrib><creatorcontrib>McGeorge, Gary</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Applied spectroscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kellichan, Nicola</au><au>Nordon, Alison</au><au>Matousek, Pavel</au><au>Littlejohn, David</au><au>McGeorge, Gary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variation in the Transmission Near-Infrared Signal with Depth in Turbid Media</atitle><jtitle>Applied spectroscopy</jtitle><addtitle>Appl Spectrosc</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>68</volume><issue>3</issue><spage>383</spage><epage>387</epage><pages>383-387</pages><issn>0003-7028</issn><eissn>1943-3530</eissn><abstract>Transmission near-infrared (NIR) measurements of a 1 mm thick aspirin disk were made at different positions as it was moved through a stack of eight 0.5 mm thick disks of microcrystalline cellulose (Avicel). 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subjects | Absorption Aspirin Cellulose Cellulose - chemistry Disks Dosage Forms Interlayers Models, Chemical Photons Spectrometry Spectroscopy Spectroscopy, Near-Infrared - methods Stacks |
title | Variation in the Transmission Near-Infrared Signal with Depth in Turbid Media |
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