Impact of Health Literacy on Medication Adherence: A Systematic Review and Meta-analysis

Objective: To systematically review the literature and estimate the effect size of the relationship between health literacy and medication adherence through meta-analysis. Data Sources: Databases searched included Cumulative Index to Nursing and Allied Health Literature (CINAHL; 1982-2013), Internat...

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Bibliographic Details
Published in:Annals of Pharmacotherapy 2014-06, Vol.48 (6), p.741-751
Main Authors: Zhang, Ning Jackie, Terry, Amanda, McHorney, Colleen A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Health Literacy - statistics & numerical data
Humans
Medical sciences
Medication Adherence - statistics & numerical data
Pharmacology. Drug treatments
Citations: Items that this one cites
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Summary:Objective: To systematically review the literature and estimate the effect size of the relationship between health literacy and medication adherence through meta-analysis. Data Sources: Databases searched included Cumulative Index to Nursing and Allied Health Literature (CINAHL; 1982-2013), International Pharmaceutical Abstracts (IPA; 1970-2013), MEDLINE OVID (1966-2013), PubMed (1966-2013), PsycInfo (1966-2013), and Web of Science (1966-2013). Study Selection and Data Extraction: Inclusion criteria were as follows: English language; published through May 1, 2013; medication adherence as the outcome variable; use of validated measures of health literacy and medication adherence; availability of a direct (not mediating) relationship between health literacy and medication adherence; and identifiable effect size and statistical significance of the relationship. Exclusion criteria were as follows: duplicated results, irrelevant results, conference abstracts, proceeding papers, books, dissertations, reviews, editorial letters, continuing education units, or book reviews. Data included author, publication year, disease area, sample size, sampling method, location, study design, effect size of the relationship between health literacy and medication adherence, and measures of health literacy and medication adherence. Data Synthesis: There is a small statistically significant and positive association between health literacy and medication adherence. In the conservative results, the unweighted and weighted correlation coefficients were 0.081 and 0.056 with P values
ISSN:1060-0280
1542-6270
DOI:10.1177/1060028014526562