Risk of coronary heart disease associated with metabolic syndrome and its individual components in Iranian subjects: A matched cohort study

Background and Objectives To evaluate the risk of coronary heart disease (CHD) associated with metabolic syndrome (MetS) and its individual components in a representative sample of diabetic and nondiabetic Iranians. Moreover, we aimed to define the most hazardous MetS components. Methods Two cohorts...

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Bibliographic Details
Published in:Journal of clinical lipidology 2014-05, Vol.8 (3), p.279-286
Main Authors: Esteghamati, Alireza, MD, Hafezi-Nejad, Nima, MPH, MD, Sheikhbahaei, Sara, MPH, MD, Heidari, Behnam, MPH, MD, Zandieh, Ali, MPH, MD, Ebadi, Maryam, MD, Nakhjavani, Manouchehr, MD
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Cardiovascular
Cholesterol - metabolism
Cohort
Cohort Studies
Coronary Disease - epidemiology
Coronary heart disease
Diabetes Complications - epidemiology
Epidemiology
Female
Follow-Up Studies
Humans
Hypertension
Hypertriglyceridemia
Incidence
Iran
Lipoproteins, HDL - metabolism
Low HDL-C
Male
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Middle Aged
Risk Factors
Sex Factors
Triglycerides - metabolism
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Summary:Background and Objectives To evaluate the risk of coronary heart disease (CHD) associated with metabolic syndrome (MetS) and its individual components in a representative sample of diabetic and nondiabetic Iranians. Moreover, we aimed to define the most hazardous MetS components. Methods Two cohorts consisting of 1737 nondiabetic and 2385 diabetic participants were followed for the first CHD event during 8.5 years (until December 2013). Results MetS is defined as having 3 individual components associated with increased risk of CHD (hazard ratio [HR] for MetS: in the unadjusted were 2.85 [2.27–3.57] and in the fully adjusted model 1.80 [1.42–2.28]). MetS was associated with lower hazard of CHD in subjects older than 65 (HR: 1.50 vs. 3.47; P for interaction < .05) and in men (HR: 1.68 vs. 4.87; P for interaction
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2014.02.002