Can paraoxonase 1 polymorphisms (L55 M and Q192 R) protect children with type 1 diabetes against lipid abnormalities?

Background Only a few studies have focused on the possible modulatory role of paraoxonase 1 (PON1) polymorphisms in lipid profiles, especially in children and in adolescents with type 1 diabetes (T1D). Objective We propose to study the association between PON1 polymorphisms (PON1-55 and PON1-192) an...

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Published in:Journal of clinical lipidology 2014-05, Vol.8 (3), p.249-255
Main Authors: Fekih, Ons, PhD, Triki, Sonia, PhD, Hellara, Ilhem, PharmD, Neffati, Fadoua, PharmD, Rejeb, Jihen, PhD, Ommezzine, Asma, PharmD, Chouchane, Slaheddine, MD, Guediche, Mohamed Neji, MD, Bouslama, Ali, PharmD, Najjar, Mohamed Fadhel, PharmD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Apolipoproteins - metabolism
Aryldialkylphosphatase - genetics
Aryldialkylphosphatase - metabolism
Cardiovascular
Cardiovascular risk
Child
Cholesterol - metabolism
Diabetes Mellitus, Type 1 - genetics
Female
Gene Frequency
Genotype
Haplotypes
Humans
Lipid disorders
Lipid Metabolism Disorders - genetics
Male
Paraoxonase 1 activity
Paraoxonase 1 polymorphisms
Polymorphism, Genetic
Spectrometry, Fluorescence
Tunisia
Type 1 diabetes
Young Adult
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Summary:Background Only a few studies have focused on the possible modulatory role of paraoxonase 1 (PON1) polymorphisms in lipid profiles, especially in children and in adolescents with type 1 diabetes (T1D). Objective We propose to study the association between PON1 polymorphisms (PON1-55 and PON1-192) and a lipid profile in a young Tunisian population with T1D. Methods The study compared 122 children and adolescents with T1D with 97 controls. Genomic DNA was collected from 116 patients and 91 controls. Lipid parameters were determined by automated methods. PON1 activity was measured by a spectrophotometric method and genotyping of the PON1 gene was assessed by multiplex polymerase chain reaction followed by restriction fragment-length polymorphism. Results A significant increase in total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B (ApoB), and lipoprotein (a) (Lp(a)) and a significant decrease in apolipoprotein A1 (ApoA1), ApoA1/ApoB ratio, and PON1 activity/HDL-C ratio were observed in children with T1D compared with controls. In the LLQR haplotype, the group with diabetes showed significantly higher values of total cholesterol, LDL-C, apoB, Lp(a), and apoA1/apoB ratio compared with the control group. Those with diabetes with the LLQQ haplotype showed a significant decrease in LDL-C and Lp(a) compared with controls ( P  
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2014.03.001