Prevalence and severity of ventricular dysfunction in patients with HIV-related pulmonary arterial hypertension

Abstract Objectives To evaluate the occurrence of ventricular systolic dysfunction in human immunodeficiency virus (HIV)-related pulmonary arterial hypertension (PAH). Background Patients with HIV-related PAH may develop ventricular systolic dysfunction both as a consequence of PAH progression or of...

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Bibliographic Details
Published in:Heart & lung 2014-05, Vol.43 (3), p.256-261
Main Authors: Dellegrottaglie, Santo, MD, PhD, García-Alvarez, Ana, MD, MSc, Guarini, Pasquale, MD, Perrone-Filardi, Pasquale, MD, PhD, Fuster, Valentin, MD, PhD, Sanz, Javier, MD
Format: Article
Language:English
Subjects:
Aged
Cardiovascular
Critical Care
Familial Primary Pulmonary Hypertension
Female
HIV
HIV Infections - complications
Human immunodeficiency virus
Humans
Hypertension, Pulmonary - complications
Magnetic Resonance Imaging
Male
Middle Aged
NMR
Nuclear magnetic resonance
Prevalence
Pulmonary hypertension
Pulmonary/Respiratory
Retrospective Studies
Stroke Volume
Systole
Ventricular Dysfunction - epidemiology
Ventricular Dysfunction - etiology
Ventricular function
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Summary:Abstract Objectives To evaluate the occurrence of ventricular systolic dysfunction in human immunodeficiency virus (HIV)-related pulmonary arterial hypertension (PAH). Background Patients with HIV-related PAH may develop ventricular systolic dysfunction both as a consequence of PAH progression or of the myocardial involvement from the HIV infection itself. Methods Cardiac magnetic resonance imaging was applied to measure ejection fraction for the left ventricle and the right ventricle in patients with HIV-related PAH ( n  = 27) and in patients with PAH from other aetiologies ( n  = 115). Results In HIV-related PAH, ejection fraction values were lower and a higher proportion of patients presented with an advanced stage of ventricular dysfunction (55% vs. 25%; p  = 0.009). In a multivariate model, PAH related to HIV infection remained independently associated with advanced ventricular dysfunction ( p  = 0.011). Conclusions Patients with HIV-related PAH have more prevalent and severe ventricular systolic dysfunction compared to patients with PAH from other aetiologies.
ISSN:0147-9563
1527-3288
DOI:10.1016/j.hrtlng.2014.02.007