Activation of prelimbic 5-HT1A receptors produces antidepressant-like effects in a unilateral rat model of Parkinson’s disease

• Published in: Neuroscience 2014-05, Vol.268, p.265-275
• Main Authors: Hui, Y.P, Zhang, Q.J, Zhang, L, Chen, L, Guo, Y, Qiao, H.F, Wang, Y, Liu, J
• Format: Article
• Language: English
• Subjects: 5-HT1A receptors; 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology; Animals; Antidepressive Agents - pharmacology; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; depression; Depression - drug therapy; Depression - physiopathology; Dietary Sucrose - administration & dosage; Dose-Response Relationship, Drug; Down-Regulation; Excitatory Amino Acid Transporter 3 - metabolism; Food Preferences - drug effects; Food Preferences - physiology; Male; Medial Forebrain Bundle - drug effects; Medial Forebrain Bundle - physiopathology; Medical sciences; Neurology; Neurons - drug effects; Neurons - physiology; Neuropharmacology; Oxidopamine; Parkinsonian Disorders - physiopathology; Parkinsonian Disorders - psychology; Parkinson’s disease; Pharmacology. Drug treatments; Piperazines - pharmacology; prelimbic medial prefrontal cortex; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Pyridines - pharmacology; rat; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A - metabolism; Serotonin 5-HT1 Receptor Antagonists - pharmacology; Serotonin Receptor Agonists - pharmacology
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.03.033

Highlights • Unilaterally lesioning the medial forebrain bundle in rats induced the depressive-like behaviors. • Intra-prelimbic cortex of 5-HT1A agonist produced antidepressant effects in sham and lesioned rats. • Intra-prelimbic cortex of 5-HT1A antagonist produced depressive responses in two groups of rats. • The doses producing these changes in lesioned rats were higher than those in sham rats. • The lesion decreased 5-HT1A receptor expression on neuronal glutamate transporter EAAC1-ir neurons in the prelimbic cortex.