CXCR4 as a novel predictive biomarker for metastasis and poor prognosis in colorectal cancer

The clinical significance of CXCR4 expression in colorectal cancer remains unclear. The aim of this study was to investigate the expression and regulatory effects of CXCR4 in colorectal cancer and the association between CXCR4 protein expression and prognosis. The mRNA and protein expression levels...

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Bibliographic Details
Published in:Tumor biology 2014-05, Vol.35 (5), p.4171-4175
Main Authors: Gao, Ying, Li, Chunyu, Nie, Min, Lu, Yao, Lin, Shunsen, Yuan, Peng, Sun, Xun
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers
Biomarkers, Tumor - analysis
Biomedical and Life Sciences
Biomedicine
Cancer Research
Colorectal cancer
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Female
Humans
Liver Neoplasms - secondary
Logistic Models
Male
Medical diagnosis
Metastasis
Middle Aged
Neoplasm Staging
Prognosis
Proportional Hazards Models
Receptors, CXCR4 - analysis
Receptors, CXCR4 - physiology
Research Article
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Summary:The clinical significance of CXCR4 expression in colorectal cancer remains unclear. The aim of this study was to investigate the expression and regulatory effects of CXCR4 in colorectal cancer and the association between CXCR4 protein expression and prognosis. The mRNA and protein expression levels of CXCR4 were determined using reverse-transcriptase polymerase chain reaction and immunohistochemistry staining, respectively, and the relationship between the CXCR4 protein level and clinicopathological parameters was analyzed in 720 cases of colorectal cancer. CXCR4 expression was elevated in colorectal cancer tissues compared to pericancerous tissues ( P  = 0.001). Of the 720 enrolled cases, 208 (28.89 %) expressed CXCR4. In univariate analysis, CXCR4 was found to be associated with lymph node metastasis, TNM stage, and liver metastasis ( P  = 0.001, 0.001, and 0.012, respectively). Further multivariate analysis suggested that histological grade, TNM stage, and CXCR4 expression were related to liver metastasis ( P  = 0.020, 0.01, and 0.001, respectively). In the Cox regression test, the histological grade, lymph node metastasis, TNM stage, liver metastasis, and CXCR4 expression were found to be independent prognostic factors ( P  = 0.02, 0.045, 0.01, 0.001, and 0.001, respectively). CXCR4 protein may be a potential biomarker for liver metastasis and an independent marker for survival in colorectal cancer.
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-013-1545-x