PROLONGED SUXAMETHONIUM-INDUCED NEUROMUSCULAR BLOCKADE ASSOCIATED WITH ORGANOPHOSPHATE POISONING

We report a patient, exposed to Malathion during agricultural work, who suffered a prolonged apnoea after the administration of suxamethonium. He had a normal phenotype (E1u E1u), but an extremely low plasma cholinesterase activity. The diagnosis was made by assaying cholinesterase activity and anal...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1988-08, Vol.61 (2), p.233-236
Main Authors: PEREZ, GUILLERMO, PRETEL, C.M. MARTINEZ, ROYO, F. TARIN, MACIAS, M.J. PENA, OSSORIO, R. ALVAREZ, GOMEZ, J.A. ALVAREZ, VIDAL, C.J.
Format: Article
Language:English
Subjects:
Adult
Apnea - etiology
Biological and medical sciences
Cholinesterases - blood
Humans
Malathion - poisoning
Male
Medical sciences
Pesticides, fertilizers and other agrochemicals toxicology
Succinylcholine - adverse effects
Time Factors
Toxicology
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Summary:We report a patient, exposed to Malathion during agricultural work, who suffered a prolonged apnoea after the administration of suxamethonium. He had a normal phenotype (E1u E1u), but an extremely low plasma cholinesterase activity. The diagnosis was made by assaying cholinesterase activity and analysing the enzymic components by electrophoresis on polyacrylamide gel slabs. The results indicated that the apnoea was a result of the low activity of plasma cholinesterase induced by Malathion.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/61.2.233