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Induction of interleukin-2 receptor- alpha gene expression is regulated by post-translational activation of mu B specific DNA binding proteins
T cell mitogens induce the expression of specific trans-acting DNA binding proteins that in turn regulate the expression of the interleukin-2 receptor- alpha (IL-2R alpha ) gene. To investigate whether de novo protein synthesis is required for the activation of these transacting factors and the indu...
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| Published in: | The Journal of biological chemistry 1989-01, Vol.264 (15), p.8475-8478 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 8478 |
| container_issue | 15 |
| container_start_page | 8475 |
| container_title | The Journal of biological chemistry |
| container_volume | 264 |
| creator | Boehnlein, E Ballard, D W Bogerd, H Peffer, N J Lowenthal, J W Greene, W C |
| description | T cell mitogens induce the expression of specific trans-acting DNA binding proteins that in turn regulate the expression of the interleukin-2 receptor- alpha (IL-2R alpha ) gene. To investigate whether de novo protein synthesis is required for the activation of these transacting factors and the induced expression of this receptor gene, Jurkat T cells were incubated with various inhibitors of protein synthesis prior to stimulation with phytohemagglutinin and phorbol 12-myristate 13-acetate (PMA). The findings support a post-translational mechanism of induction of pre-existing, but inactive, DNA binding proteins which in turn bind to and activate the IL-2R alpha gene. |
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| identifier | ISSN: 0021-9258 |
| ispartof | The Journal of biological chemistry, 1989-01, Vol.264 (15), p.8475-8478 |
| issn | 0021-9258 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15215998 |
| source | ScienceDirect Journals |
| title | Induction of interleukin-2 receptor- alpha gene expression is regulated by post-translational activation of mu B specific DNA binding proteins |
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