Structure of the gene for cartilage matrix protein, a modular protein of the extracellular matrix. Exon/intron organization, unusual splice sites, and relation to alpha chains of beta sub(2) integrins, von Willebrand factor, complement factors B and C2, and epidermal growth factor

The entire gene for chicken cartilage matrix protein (CMP) has been isolated and characterized by restriction mapping, electron microscopy, nuclease S1 mapping, and sequence analysis. The gene, which is present in a single copy in the chicken genome, is 18 kilobase pairs long and comprises eight exo...

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Bibliographic Details
Published in:The Journal of biological chemistry 1989-01, Vol.264 (14), p.8126-8134
Main Authors: Kiss, I, Deak, F, Holloway, RG Jr, Delius, H, Mebust, KA, Frimberger, E, Argraves, W S, Tsonis, P A, Goetinck, P F
Format: Article
Language:English
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Summary:The entire gene for chicken cartilage matrix protein (CMP) has been isolated and characterized by restriction mapping, electron microscopy, nuclease S1 mapping, and sequence analysis. The gene, which is present in a single copy in the chicken genome, is 18 kilobase pairs long and comprises eight exons and seven introns. It has two transcription initiation sites, 8 base pairs from each other. A sequence very homologous to the consensus nuclear factor III binding-site sequence, a CAT-and a TATA-like sequence are found in the promoter region and ATTAAA is used as a polyadenylation signal.
ISSN:0021-9258