Quantitative histological analysis and ultrastructure of the aging human testis

Purpose To quantitatively assess the histological and ultrastructural changes resulting from aging in the human testis. Methods Age-related histological and ultrastructural changes were evaluated using light microscopy, transmission electron microscopy (TEM) and immunohistochemistry on 41 testicular...

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Bibliographic Details
Published in:International urology and nephrology 2014-05, Vol.46 (5), p.879-885
Main Authors: Jiang, Huan, Zhu, Wei-Jie, Li, Jing, Chen, Qiu-Ju, Liang, Wei-Bo, Gu, Yi-Qun
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging - physiology
Apoptosis
Cell Proliferation
Humans
Immunohistochemistry
Male
Medicine
Medicine & Public Health
Microscopy, Electron, Transmission
Middle Aged
Nephrology
Sertoli Cells - cytology
Spermatids - cytology
Spermatocytes - cytology
Spermatogenesis
Spermatogonia - cytology
Spermatozoa - cytology
Testis - anatomy & histology
Testis - chemistry
Testis - ultrastructure
Urology
Urology - Original Paper
Young Adult
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Summary:Purpose To quantitatively assess the histological and ultrastructural changes resulting from aging in the human testis. Methods Age-related histological and ultrastructural changes were evaluated using light microscopy, transmission electron microscopy (TEM) and immunohistochemistry on 41 testicular samples obtained from elderly men and, respectively, assigned to group A ( n  = 20), 54–69 years old or group B ( n  = 21), 70–89 years old. Testicular samples derived from 17 young men were used for control. Results The numbers of Sertoli cells in the aged groups were significantly lower than that in the controls ( p  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-013-0610-0