Association of serum total testosterone concentration with skeletal muscle mass in men under hemodialysis

• Published in: International urology and nephrology 2014-05, Vol.46 (5), p.985-991
• Main Authors: Kojo, Gloria, Yoshida, Takuya, Ohkawa, Sakae, Odamaki, Mari, Kato, Akihiko, Takita, Takako, Maruyama, Yukitaka, Kumagai, Hiromichi
• Format: Article
• Language: English
• Subjects: Abdominal Muscles - diagnostic imaging; Abdominal Muscles - pathology; Adult; Age Factors; Aged; Aged, 80 and over; C-Reactive Protein - metabolism; Creatinine - blood; Humans; Interleukin-6 - blood; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Nephrology - Original Paper; Organ Size; Renal Dialysis; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - therapy; Testosterone - blood; Thigh - diagnostic imaging; Thigh - pathology; Tomography, X-Ray Computed; Urology
• ISSN: 0301-1623; 1573-2584
• DOI: 10.1007/s11255-013-0543-7

Purpose Although skeletal muscle wasting can occur in chronic kidney diseases, its relationship with the serum testosterone concentration remains uncertain. This study investigates the relationship between serum testosterone and skeletal muscle mass in men under hemodialysis (HD). Methods Sixty men aged between 41 and 89 years undergoing HD for 15.0 ± 8.1 years were enrolled for this study. The muscle areas of the thigh (TMA) and abdomen (AMA) were measured by computed tomography (CT), and the association between these muscle areas and serum total testosterone was examined with adjustment of age and other nutritional variables. Results The mean serum total testosterone in our HD patients (6.33 ± 2.90 ng/mL) was not lower than that of the Japanese general population, but showed a positive correlation with TMA ( r  = 0.39, p