Assessment of acute bronchodilator effects from specific airway resistance changes in stable COPD patients

Highlights • In COPD patients, acute bronchodilator response is currently assessed in terms of FEV1 and FVC changes, according to ATS/ERS criteria. • These changes are poorly associated to beneficial effects of bronchodilation, such as reduction of hyperinflation, gas trapping, and dyspnea. • In COP...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2014-06, Vol.197, p.36-45
Main Authors: Santus, Pierachille, Radovanovic, Dejan, Henchi, Sonia, Di Marco, Fabiano, Centanni, Stefano, D’Angelo, Edgardo, Pecchiari, Matteo
Format: Article
Language:English
Subjects:
Adrenergic beta-agonists
Adrenergic beta-Agonists - therapeutic use
Aged
Airway Resistance - drug effects
Bronchodilator Agents - therapeutic use
Cross-Over Studies
Double-Blind Method
Dyspnea
Dyspnea - drug therapy
Dyspnea - physiopathology
Female
Humans
Indans - therapeutic use
Lung Volume Measurements
Male
Medical Education
Plethysmography
Pulmonary Disease, Chronic Obstructive - drug therapy
Pulmonary Disease, Chronic Obstructive - physiopathology
Pulmonary/Respiratory
Quinolones - therapeutic use
Respiratory Function Tests
Reversibility
Short-term variability
Time Factors
Treatment Outcome
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Summary:Highlights • In COPD patients, acute bronchodilator response is currently assessed in terms of FEV1 and FVC changes, according to ATS/ERS criteria. • These changes are poorly associated to beneficial effects of bronchodilation, such as reduction of hyperinflation, gas trapping, and dyspnea. • In COPD patients, bronchodilator induced changes of total airway resistance were closely related to improvements of lung mechanics and dyspnea. • In contrast, concomitant changes of FEV1 correlated with those of FVC only. • Changes of total specific airway resistance better identify the beneficial impact of bronchodilators.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2014.03.012