Potentiation by Caffeine of Potentially Lethal Fast-Neutron Damage in Cultured Human Cells

Caffeine was found to potentiate single-dose fast-neutron-induced killing of human T-1 cells when present at 2 mM for 60 hr or more after (and 10 hr before) irradiation. Analyses of survival curves of cells treated with neutrons or X rays with and without caffeine indicate that only the linear, low-...

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Bibliographic Details
Published in:Radiation research 1980-11, Vol.84 (2), p.353-358
Main Authors: Schroy, Carter B., Furcinitti, Paul S., Todd, Paul, Kukulinsky, Nancy E.
Format: Article
Language:English
Subjects:
Caffeine - pharmacology
Cell culture techniques
Cell lines
Cell Survival - drug effects
Cell Survival - radiation effects
Cells
Cells, Cultured
CHO cells
Correspondence
Cultured cells
DNA - radiation effects
DNA damage
Dose-Response Relationship, Radiation
Fast Neutrons
HeLa cells
Humans
Irradiation
Neutrons
Radiation damage
Time Factors
X-Rays
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Summary:Caffeine was found to potentiate single-dose fast-neutron-induced killing of human T-1 cells when present at 2 mM for 60 hr or more after (and 10 hr before) irradiation. Analyses of survival curves of cells treated with neutrons or X rays with and without caffeine indicate that only the linear, low-dose portion of survival curves is modified. Potentiation of lethality by caffeine is attributed mainly to its effects on single-hit potentially lethal lesions, possibly certain DNA double-strand breaks.
ISSN:0033-7587
1938-5404
DOI:10.2307/3575305