Increased risk of preterm delivery and pre‐eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia

Objective To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), and to examine the role of hyperandrogenaemia. Design Cohort study. Setting Singleton pregnancies in women with PCOS identified at a private fertility clinic during 1997–2010 and a background po...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2014-04, Vol.121 (5), p.575-581
Main Authors: Naver, KV, Grinsted, J, Larsen, SO, Hedley, PL, Jørgensen, FS, Christiansen, M, Nilas, L
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Case-Control Studies
Cohort Studies
Female
Humans
Hyperandrogenaemia
Hyperandrogenism - epidemiology
Infant, Newborn
Infant, Small for Gestational Age
Maternal Age
Obstetrics
Parity
Polycystic ovary syndrome
Polycystic Ovary Syndrome - epidemiology
Pre-Eclampsia - epidemiology
Pregnancy
Premature birth
Premature Birth - epidemiology
preterm delivery
pre‐eclampsia
Regression Analysis
Risk factors
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Summary:Objective To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), and to examine the role of hyperandrogenaemia. Design Cohort study. Setting Singleton pregnancies in women with PCOS identified at a private fertility clinic during 1997–2010 and a background population including all singleton deliveries at Hvidovre Hospital, Denmark, in 2005. Population A cohort of 459 women with PCOS and a background population of 5409 women. Methods Obstetric outcomes were extracted from national Danish registries and odds ratios (ORs) were calculated by multiple logistic regression analysis, adjusting for age, parity, and body mass index. Main outcome measures Risk of pre‐eclampsia, preterm delivery, and small for gestational age offspring in the entire PCOS population and in a subsample with hyperandrogenaemia. Results Women with PCOS had an increased risk of preterm delivery
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.12558