Oncologic Resection Achieving R0 Margins Improves Disease-Free Survival in Parathyroid Cancer

• Published in: Annals of surgical oncology 2014-06, Vol.21 (6), p.1891-1897
• Main Authors: Schulte, K. M., Talat, N., Galata, G., Gilbert, J., Miell, J., Hofbauer, L. C., Barthel, A., Diaz-Cano, S., Bornstein, S. R.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Disease-Free Survival; Endocrine Tumors; Female; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neck Dissection; Neoplasm Recurrence, Local; Neoplasm, Residual; Oncology; Parathyroid Neoplasms - mortality; Parathyroid Neoplasms - surgery; Reoperation; Retrospective Studies; Surgery; Surgical Oncology
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-014-3530-z

Background Parathyroid cancer has a poor mid-term prognosis, often because of local recurrence, observed in half of all patients. Modern diagnostic workup increasingly enables a preoperative diagnosis of parathyroid cancer. There is limited evidence that more comprehensive oncologic surgery can reduce the risk of local recurrence. This study aims to identify the best specific surgical approach in parathyroid cancer. Methods This observational cohort study comprises 19 consecutive patients who had undergone oncologic or nononcologic resection for parathyroid cancer. Baseline parameters were compared by using univariate analysis; outcomes were assessed by χ 2 testing and Kaplan–Meier statistics. Results Fifteen of 19 patients were primarily operated on in our tertiary center between 1996 and 2013, and four were referred for follow-up because of their cancer diagnosis. Patient cohorts defined by histologic R-status were comparable for established risk factors: sex, calcium levels, low-risk/high-risk status, and presence of vascular invasion. Oncologic resections were performed in 13 of 15 patients primarily treated in the center and 0 of 4 treated elsewhere ( χ 2  = 5.6; p