Calcitonin and 1,25-Dihydroxyvitamin D sub(3) Receptors in Human Breast Cancer Cell Lines

Five human breast cancer cell lines and a human breast epithelial cell line have been found to contain specific high-affinity receptors for 1,25-dihydroxyvitamin D sub(3). K sub(d) values ranged from 0.6 to 2.0 X 10 super(-) super(1) super(1) M and receptor concentration from 31 to 150 fmol/mg cytos...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1980-01, Vol.40 (12), p.4764-4767
Main Authors: Findlay, D M, Michelangeli, V P, Eisman, JA, Frampton, R J, Moseley, J M, Whitehead, R
Format: Article
Language:English
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Summary:Five human breast cancer cell lines and a human breast epithelial cell line have been found to contain specific high-affinity receptors for 1,25-dihydroxyvitamin D sub(3). K sub(d) values ranged from 0.6 to 2.0 X 10 super(-) super(1) super(1) M and receptor concentration from 31 to 150 fmol/mg cytosol protein. Two of the breast cancer lines contain specific high-affinity receptors for calcitonin and a calcitonin-responsive adenylate cyclase, which have been characterized with the aid of salmon, eel, and human calcitonins and in several substituted analogues of human calcitonin. The 1,25-dihydroxyvitamin D sub(3) receptor may reflect a normal property of the breast cell. Breast cancer cell lines provide a useful source of 1,25-dihydroxyvitamin D sub(3) receptors.
ISSN:0008-5472