Autophagy-targeted vaccine of LC3–LpqH DNA and its protective immunity in a murine model of tuberculosis

Highlights • A novel autophagy-targeted vaccine of LpqH DNA harboring LC3 was presented. • A certain relationship exists between LpqH and autophagy induction. • Localization of LpqH at autophagosome was targeted by LC3. • Enhanced protective efficacy and immune responses were induced by this vaccine...

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Bibliographic Details
Published in:Vaccine 2014-04, Vol.32 (20), p.2308-2314
Main Authors: Hu, Dong, Wu, Jing, Zhang, Rongbo, Chen, Liping, Chen, Zhaoquan, Wang, Xuefeng, Xu, Lifa, Xiao, Jian, Hu, Fengyu, Wu, Changyou
Format: Article
Language:English
Subjects:
Ag85B
Allergy and Immunology
Animals
Antibodies, Bacterial - blood
Applied microbiology
Autophagy
Bacterial Load
Bacterial Proteins - immunology
Bacteriology
Biological and medical sciences
Cell Line
Colleges & universities
Cytokines - immunology
Deoxyribonucleic acid
DNA
Female
Fundamental and applied biological sciences. Psychology
Genetic engineering
Immune response
Immunization
Kinases
LC3
Lipoproteins
Lipoproteins - immunology
LpqH
Lung - microbiology
Mice
Mice, Inbred BALB C
Microbiology
Microtubule-Associated Proteins - immunology
Miscellaneous
Mycobacterium
Mycobacterium tuberculosis
Phagosomes - immunology
Plasmids
Protective immunity
Proteins
Recombinant Fusion Proteins - immunology
Science
Spleen - microbiology
Tuberculosis
Tuberculosis - prevention & control
Tuberculosis Vaccines - immunology
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, DNA - immunology
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Summary:Highlights • A novel autophagy-targeted vaccine of LpqH DNA harboring LC3 was presented. • A certain relationship exists between LpqH and autophagy induction. • Localization of LpqH at autophagosome was targeted by LC3. • Enhanced protective efficacy and immune responses were induced by this vaccine. • A simple and powerful strategy to enhance vaccine efficacy is to access autophagy.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.02.069