SOCS signaling in autoimmune diseases: Molecular mechanisms and therapeutic implications

Suppressor of cytokine signaling (SOCS) proteins are mainly induced by various cytokines and have been described as classical inhibitors of cytokine signaling. SOCS signaling is involved in the regulation of immune cells, and recent findings suggest that SOCS proteins, especially SOCS1 and SOCS3, ar...

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Bibliographic Details
Published in:European journal of immunology 2014-05, Vol.44 (5), p.1265-1275
Main Authors: Liang, Yan, Xu, Wang‐Dong, Peng, Hui, Pan, Hai‐Feng, Ye, Dong‐Qing
Format: Article
Language:English
Subjects:
Animals
Autoimmune disease
Autoimmune diseases
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmune Diseases - therapy
Cytokines
Humans
Proteins
Signal Transduction - immunology
Signaling pathways
Suppressor of cytokine signaling
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling 3 Protein
Suppressor of Cytokine Signaling Proteins - immunology
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Summary:Suppressor of cytokine signaling (SOCS) proteins are mainly induced by various cytokines and have been described as classical inhibitors of cytokine signaling. SOCS signaling is involved in the regulation of immune cells, and recent findings suggest that SOCS proteins, especially SOCS1 and SOCS3, are often dysregulated in a wide variety of autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, psoriasis, and multiple sclerosis. Recent studies suggest that SOCS signaling could be therapeutically targeted in various autoimmune diseases. In this review, we discuss recent studies on the role of SOCS proteins in the development and pathogenesis of autoimmune diseases, as well as their clinical implications.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201344369