Singular Expression of Olfactory Receptor Genes

Understanding the mechanisms of monogenic and monoallelic transcription of the large repertoire of olfactory receptor genes represents a challenging task. A picture is now emerging in which odorant receptor choice and stabilization involve an escape from silencing followed by the activation of an un...

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Bibliographic Details
Published in:Cell 2013-10, Vol.155 (2), p.274-277
Main Author: Rodriguez, Ivan
Format: Article
Language:English
Subjects:
Animals
Feedback
Gene Expression Regulation
genes
Humans
odor compounds
Olfactory Receptor Neurons - metabolism
olfactory receptors
Receptors, Odorant - genetics
Receptors, Odorant - metabolism
Stochastic Processes
Transcription, Genetic
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Description
Summary:Understanding the mechanisms of monogenic and monoallelic transcription of the large repertoire of olfactory receptor genes represents a challenging task. A picture is now emerging in which odorant receptor choice and stabilization involve an escape from silencing followed by the activation of an unconventional feedback loop.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2013.09.032