Physico-functional and mechanical properties of chitosan and calcium salts incorporated fish gelatin scaffolds

Four types of fish gelatin scaffolds viz. gelatin (G), gelatin–chitosan (GC), gelatin–calcium acetate (GCA) and gelatin–chitosan–calcium acetate (GCCA) prepared were investigated for their functional properties, biomechanical strength, microstructural changes in relation to biodegradation. GC scaffo...

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Bibliographic Details
Published in:International journal of biological macromolecules 2013-09, Vol.60, p.262-267
Main Authors: Jeevithan, E., Jeya Shakila, R., Varatharajakumar, A., Jeyasekaran, G., Sukumar, D.
Format: Article
Language:English
Subjects:
Animals
Bio-degradation
Biocompatible Materials - chemistry
Calcium - chemistry
Chitosan - chemistry
Fish gelatin
Fishes - genetics
Gelatin - chemistry
Hydrogen-Ion Concentration
Mechanical Phenomena
Mechanical properties
Microstructure
Salts - chemistry
Scaffold
Tissue Scaffolds - chemistry
Viscosity
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Summary:Four types of fish gelatin scaffolds viz. gelatin (G), gelatin–chitosan (GC), gelatin–calcium acetate (GCA) and gelatin–chitosan–calcium acetate (GCCA) prepared were investigated for their functional properties, biomechanical strength, microstructural changes in relation to biodegradation. GC scaffold was superior with pH 3.15 and viscosity 9.40cP. Chitosan and calcium acetate improved tensile strength (TS) and Young's modulus (YM), but lowered elongation at break (EAB). GCCA scaffold possessed moderate TS of 19.6MPa, EAB of 4.76% and YM of 185MPa. Foaming ability ratio of GC scaffold was high (3.41). GCA and GCCA scaffolds remained for 4 days before complete in vitro biodegradation. GC scaffold had larger cavities (180–300μm) that were responsible for low swelling ratios and shrinkage factor. GCCA scaffold with moderate swelling rates, mechanical, functional properties and lowered biodegradation rate were found more suitable for biomedical applications.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2013.06.012