Breaking down the wall: the nuclear envelope during mitosis

Highlights • The nuclear envelope (NE) is actively remodeled during mitosis. • Microtubule-organizing centers (MTOCs) insert into the NE in closed mitosis. • The NE disassembles during open mitosis to facilitate spindle formation. • Membrane bending, composition and stabilization are associated with...

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Bibliographic Details
Published in:Current opinion in cell biology 2014-02, Vol.26, p.1-9
Main Authors: Smoyer, Christine J, Jaspersen, Sue L
Format: Article
Language:English
Subjects:
Biological Transport
Cytoplasm - genetics
Cytoplasm - metabolism
Eukaryotic Cells - cytology
Eukaryotic Cells - metabolism
Humans
Internal Medicine
Mitosis
Nuclear Envelope - chemistry
Nuclear Envelope - genetics
Nuclear Envelope - metabolism
Nuclear Pore - metabolism
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Summary:Highlights • The nuclear envelope (NE) is actively remodeled during mitosis. • Microtubule-organizing centers (MTOCs) insert into the NE in closed mitosis. • The NE disassembles during open mitosis to facilitate spindle formation. • Membrane bending, composition and stabilization are associated with MTOCs.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2013.08.002