pH-Triggered Aggregate Shape of Different Generations Lysine-Dendronized Maleimide Copolymers with Maltose Shell

Glycopolymers are promising materials in the field of biomedical applications and in the fabrication of supramolecular structures with specific functions. For tunable design of supramolecular structures, glycopolymer architectures with specific properties (e.g., controlled self-assembly) are needed....

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Bibliographic Details
Published in:Biomacromolecules 2012-12, Vol.13 (12), p.4222-4235
Main Authors: Boye, S, Appelhans, D, Boyko, V, Zschoche, S, Komber, H, Friedel, P, Formanek, P, Janke, A, Voit, B. I, Lederer, A
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Chromatography, Gel
Dendrimers - chemistry
Fractionation, Field Flow
Hydrogen-Ion Concentration
Lysine - chemistry
Macromolecular Substances
Maleimides - chemistry
Maltose - chemistry
Microscopy, Atomic Force
Microscopy, Electron, Transmission
Models, Molecular
Molecular Dynamics Simulation
Molecular Structure
Polymers - chemistry
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Summary:Glycopolymers are promising materials in the field of biomedical applications and in the fabrication of supramolecular structures with specific functions. For tunable design of supramolecular structures, glycopolymer architectures with specific properties (e.g., controlled self-assembly) are needed. Using the concept of dendronized polymers, a series of H-bond active giant glycomacromolecules with maleimide backbone and lysine dendrons of different generations were synthesized. They possess different macromolecular size and functionality along the backbone. Their peripheral maltose units lead to solubility under physiological conditions and controlled aggregation behavior. The aggregation behavior was investigated depending on generation number, pH value, and concentration. A portfolio of complementary analytical tools give an insight into the influence of the different parameters in shaping a rod-, coil-, and worm-like molecular structure and their controlled aggregate formation. MD simulation helped us to understand the complex aggregation behavior of the linear polymer chain without dendritic units.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm301489s