Antiviral Chromones from the Stem of Cassia siamea

Seven new chromones, siamchromones A–G (1–7), and 12 known chromones (8–19) were isolated from the stems of Cassia siamea. Compounds 1–19 were evaluated for their antitobacco mosaic virus (anti-TMV) and anti-HIV-1 activities. Compound 6 showed antitobacco mosaic virus (anti-TMV) activity with an inh...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2012-11, Vol.75 (11), p.1909-1914
Main Authors: Hu, Qiu-Fen, Zhou, Bin, Gao, Xue-Mei, Yang, Li-Ying, Shu, Li-Dan, Shen, Yanqiong, Li, Gan-Peng, Che, Chun-Tao, Yang, Guang-Yu
Format: Article
Language:English
Subjects:
Antiviral Agents - pharmacology
Cassia - chemistry
Cassia siamea
Chromones - chemistry
Chromones - isolation & purification
Chromones - pharmacology
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
HIV-1 - drug effects
Molecular Structure
Plant Stems - chemistry
Tobacco Mosaic Virus - drug effects
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Summary:Seven new chromones, siamchromones A–G (1–7), and 12 known chromones (8–19) were isolated from the stems of Cassia siamea. Compounds 1–19 were evaluated for their antitobacco mosaic virus (anti-TMV) and anti-HIV-1 activities. Compound 6 showed antitobacco mosaic virus (anti-TMV) activity with an inhibition rate of 35.3% and IC50 value of 31.2 μM, which is higher than that of the positive control, ningnamycin. Compounds 1, 10, 13, and 16 showed anti-TMV activities with inhibition rates above 10%. Compounds 4, 6, 13, and 19 showed anti-HIV-1 activities with therapeutic index values above 50.
ISSN:0163-3864
1520-6025
DOI:10.1021/np300395m