Influence of the lysine on the calcium oxalate renal calculi

Plasma levels and urinary excretions of amino acid lysine were estimated by high-performance liquid chromatography in 15 control subjects and 56 stone formers (SFs) with calcium oxalate (CaOX) urolithiasis. Data demonstrated clearly that there is a general tendency toward decreased lysine’s excretio...

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Bibliographic Details
Published in:International urology and nephrology 2014-03, Vol.46 (3), p.593-597
Main Author: Atanassova, Stoyanka S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Calcium Oxalate - analysis
Female
Humans
Kidney Calculi - chemistry
Kidney Calculi - urine
Lysine - urine
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Nephrology - Original Paper
Urology
Young Adult
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Summary:Plasma levels and urinary excretions of amino acid lysine were estimated by high-performance liquid chromatography in 15 control subjects and 56 stone formers (SFs) with calcium oxalate (CaOX) urolithiasis. Data demonstrated clearly that there is a general tendency toward decreased lysine’s excretions in above 40 % of SFs. Moreover, it was found that DL-lysine, a normal physiological constituent of urine, acts at increased concentrations as a dissolving agent with respect to CaOX and CaOX calculi. The kinetics of dissolution of crystalline calcium oxalate calculi in physiological solutions containing DL-lysine at different concentrations is studied, using the change in the Archimedean weight of samples immersed in the solution. The possible effect of lysine as a natural regulator of CaOX supersaturation and crystallization in human urine is also discussed.
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-013-0532-x