Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract

The leaves of Markhamia tomentosa (Benth.) K. Schum (Bignoniaceae) are used traditionally for the treatment of oedema and rheumatoid arthritis in Nigeria. The aim of the work was to investigate the anti-inflammatory activity of the ethanolic leaf extract of Markhamia tomentosa. The extract was scree...

Full description

Saved in:
Bibliographic Details
Published in:Journal of ethnopharmacology 2013-08, Vol.149 (1), p.191-194
Main Authors: Sowemimo, Abimbola, Samuel, Femi, Fageyinbo, Muyiwa Samuel
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory activity
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Anti-Inflammatory Agents - toxicity
Bignoniaceae
Bignoniaceae - chemistry
Bignoniaceae - growth & development
Carrageenan-induced paw oedema
Disease Models, Animal
Dose-Response Relationship, Drug
edema
Edema - drug therapy
Edema - immunology
Edema - pathology
Ethanol - chemistry
Ethnopharmacology
Female
formalin
histamine
Histamine-induced paw oedema
inflammation
leaf extracts
leaves
Male
Markhamia tomentosa
Medicine, African Traditional
Mice
Nigeria
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Extracts - toxicity
Plant Leaves - chemistry
Rats
Rats, Wistar
rheumatoid arthritis
Serotonin-induced paw oedema
Toxicity Tests, Acute
Xylene-induced paw oedema
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The leaves of Markhamia tomentosa (Benth.) K. Schum (Bignoniaceae) are used traditionally for the treatment of oedema and rheumatoid arthritis in Nigeria. The aim of the work was to investigate the anti-inflammatory activity of the ethanolic leaf extract of Markhamia tomentosa. The extract was screened using the carrageenan-induced paw oedema in rats, xylene-induced oedema in mice and the formalin-induced oedema in mice at 50, 100, 200mg/kg doses p.o respectively. The mechanism by which the extract mediated the anti-inflammatory activity was assessed using the histamine-induced rat paw oedema and serotonin-induced rat paw oedema at the highest dose (200mg/kg). The results showed that the extract produced a significant dose-dependent inhibition in carrageenan-induced, xylene-induced and the formalin tests. The extract exerted a significant inhibition of 54.55% (P
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2013.06.020