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Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract
The leaves of Markhamia tomentosa (Benth.) K. Schum (Bignoniaceae) are used traditionally for the treatment of oedema and rheumatoid arthritis in Nigeria. The aim of the work was to investigate the anti-inflammatory activity of the ethanolic leaf extract of Markhamia tomentosa. The extract was scree...
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| Published in: | Journal of ethnopharmacology 2013-08, Vol.149 (1), p.191-194 |
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| creator | Sowemimo, Abimbola Samuel, Femi Fageyinbo, Muyiwa Samuel |
| description | The leaves of Markhamia tomentosa (Benth.) K. Schum (Bignoniaceae) are used traditionally for the treatment of oedema and rheumatoid arthritis in Nigeria.
The aim of the work was to investigate the anti-inflammatory activity of the ethanolic leaf extract of Markhamia tomentosa.
The extract was screened using the carrageenan-induced paw oedema in rats, xylene-induced oedema in mice and the formalin-induced oedema in mice at 50, 100, 200mg/kg doses p.o respectively. The mechanism by which the extract mediated the anti-inflammatory activity was assessed using the histamine-induced rat paw oedema and serotonin-induced rat paw oedema at the highest dose (200mg/kg).
The results showed that the extract produced a significant dose-dependent inhibition in carrageenan-induced, xylene-induced and the formalin tests. The extract exerted a significant inhibition of 54.55% (P |
| doi_str_mv | 10.1016/j.jep.2013.06.020 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1524414156</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874113004388</els_id><sourcerecordid>1426510144</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-5a2075a5b9fc51574414512bb9f017919c6a4fb10768f07ed8d75ba5204466bd3</originalsourceid><addsrcrecordid>eNqFkc1u1DAURi0EotPCA7ABL8siqe34JxGrUk0B0YpF6dq6ceyOhySe2p6q8_Z4NKXLsvK1dO7R1fch9IGSmhIqz9b12m5qRmhTE1kTRl6hBW0Vq5RQzWu0II1qq1ZxeoSOU1oTQhTl5C06Yo3qmGj5Ag3nc_aVn90I0wQ5xB0Gk_2DzzscHL6G-GcFkwecw2TnHBLg069lWNWf8c8a35jVdqrx8hEv57uxxjavYA6jN3i04LB9zLHo3qE3DsZk3z-9J-j2cvn74nt19evbj4vzq8pwJXMlgBElQPSdM4IKxTnlgrK-_AlVHe2MBO56SpRsHVF2aAclehCMcC5lPzQn6PTg3cRwv7Up68knY8cRZhu2SVPB9k4q5P9RzqQoIXNeUHpATQwpRev0JvoJ4k5Tovc96LUuPeh9D5pIXXooOx-f9Nt-ssPzxr_gC_DpADgIGu6iT_r2phh4KYm3vBOF-HIgbEnswduok_F2Nnbw0Zqsh-BfOOAv0FufPQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1426510144</pqid></control><display><type>article</type><title>Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract</title><source>Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list)</source><creator>Sowemimo, Abimbola ; Samuel, Femi ; Fageyinbo, Muyiwa Samuel</creator><creatorcontrib>Sowemimo, Abimbola ; Samuel, Femi ; Fageyinbo, Muyiwa Samuel</creatorcontrib><description>The leaves of Markhamia tomentosa (Benth.) K. Schum (Bignoniaceae) are used traditionally for the treatment of oedema and rheumatoid arthritis in Nigeria.
The aim of the work was to investigate the anti-inflammatory activity of the ethanolic leaf extract of Markhamia tomentosa.
The extract was screened using the carrageenan-induced paw oedema in rats, xylene-induced oedema in mice and the formalin-induced oedema in mice at 50, 100, 200mg/kg doses p.o respectively. The mechanism by which the extract mediated the anti-inflammatory activity was assessed using the histamine-induced rat paw oedema and serotonin-induced rat paw oedema at the highest dose (200mg/kg).
The results showed that the extract produced a significant dose-dependent inhibition in carrageenan-induced, xylene-induced and the formalin tests. The extract exerted a significant inhibition of 54.55% (P<0.0001) and 42.11% (P<0.01) at 90min in the histamine-induced and serotonin-induced rat paw oedema models respectively.
These findings suggest that the ethanolic leaf extract of Markhamia tomentosa possesses anti-inflammatory activity possibly mediated by histamine. The results justify the use of the plant in the preparation of ethno medicines used in the treatment of ailments associated with inflammation.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2013.06.020</identifier><identifier>PMID: 23792584</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Anti-Inflammatory Agents - toxicity ; Bignoniaceae ; Bignoniaceae - chemistry ; Bignoniaceae - growth & development ; Carrageenan-induced paw oedema ; Disease Models, Animal ; Dose-Response Relationship, Drug ; edema ; Edema - drug therapy ; Edema - immunology ; Edema - pathology ; Ethanol - chemistry ; Ethnopharmacology ; Female ; formalin ; histamine ; Histamine-induced paw oedema ; inflammation ; leaf extracts ; leaves ; Male ; Markhamia tomentosa ; Medicine, African Traditional ; Mice ; Nigeria ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Extracts - toxicity ; Plant Leaves - chemistry ; Rats ; Rats, Wistar ; rheumatoid arthritis ; Serotonin-induced paw oedema ; Toxicity Tests, Acute ; Xylene-induced paw oedema</subject><ispartof>Journal of ethnopharmacology, 2013-08, Vol.149 (1), p.191-194</ispartof><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-5a2075a5b9fc51574414512bb9f017919c6a4fb10768f07ed8d75ba5204466bd3</citedby><cites>FETCH-LOGICAL-c476t-5a2075a5b9fc51574414512bb9f017919c6a4fb10768f07ed8d75ba5204466bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23792584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sowemimo, Abimbola</creatorcontrib><creatorcontrib>Samuel, Femi</creatorcontrib><creatorcontrib>Fageyinbo, Muyiwa Samuel</creatorcontrib><title>Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The leaves of Markhamia tomentosa (Benth.) K. Schum (Bignoniaceae) are used traditionally for the treatment of oedema and rheumatoid arthritis in Nigeria.
The aim of the work was to investigate the anti-inflammatory activity of the ethanolic leaf extract of Markhamia tomentosa.
The extract was screened using the carrageenan-induced paw oedema in rats, xylene-induced oedema in mice and the formalin-induced oedema in mice at 50, 100, 200mg/kg doses p.o respectively. The mechanism by which the extract mediated the anti-inflammatory activity was assessed using the histamine-induced rat paw oedema and serotonin-induced rat paw oedema at the highest dose (200mg/kg).
The results showed that the extract produced a significant dose-dependent inhibition in carrageenan-induced, xylene-induced and the formalin tests. The extract exerted a significant inhibition of 54.55% (P<0.0001) and 42.11% (P<0.01) at 90min in the histamine-induced and serotonin-induced rat paw oedema models respectively.
These findings suggest that the ethanolic leaf extract of Markhamia tomentosa possesses anti-inflammatory activity possibly mediated by histamine. The results justify the use of the plant in the preparation of ethno medicines used in the treatment of ailments associated with inflammation.
[Display omitted]</description><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Anti-Inflammatory Agents - toxicity</subject><subject>Bignoniaceae</subject><subject>Bignoniaceae - chemistry</subject><subject>Bignoniaceae - growth & development</subject><subject>Carrageenan-induced paw oedema</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>edema</subject><subject>Edema - drug therapy</subject><subject>Edema - immunology</subject><subject>Edema - pathology</subject><subject>Ethanol - chemistry</subject><subject>Ethnopharmacology</subject><subject>Female</subject><subject>formalin</subject><subject>histamine</subject><subject>Histamine-induced paw oedema</subject><subject>inflammation</subject><subject>leaf extracts</subject><subject>leaves</subject><subject>Male</subject><subject>Markhamia tomentosa</subject><subject>Medicine, African Traditional</subject><subject>Mice</subject><subject>Nigeria</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Extracts - toxicity</subject><subject>Plant Leaves - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>rheumatoid arthritis</subject><subject>Serotonin-induced paw oedema</subject><subject>Toxicity Tests, Acute</subject><subject>Xylene-induced paw oedema</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAURi0EotPCA7ABL8siqe34JxGrUk0B0YpF6dq6ceyOhySe2p6q8_Z4NKXLsvK1dO7R1fch9IGSmhIqz9b12m5qRmhTE1kTRl6hBW0Vq5RQzWu0II1qq1ZxeoSOU1oTQhTl5C06Yo3qmGj5Ag3nc_aVn90I0wQ5xB0Gk_2DzzscHL6G-GcFkwecw2TnHBLg069lWNWf8c8a35jVdqrx8hEv57uxxjavYA6jN3i04LB9zLHo3qE3DsZk3z-9J-j2cvn74nt19evbj4vzq8pwJXMlgBElQPSdM4IKxTnlgrK-_AlVHe2MBO56SpRsHVF2aAclehCMcC5lPzQn6PTg3cRwv7Up68knY8cRZhu2SVPB9k4q5P9RzqQoIXNeUHpATQwpRev0JvoJ4k5Tovc96LUuPeh9D5pIXXooOx-f9Nt-ssPzxr_gC_DpADgIGu6iT_r2phh4KYm3vBOF-HIgbEnswduok_F2Nnbw0Zqsh-BfOOAv0FufPQ</recordid><startdate>20130826</startdate><enddate>20130826</enddate><creator>Sowemimo, Abimbola</creator><creator>Samuel, Femi</creator><creator>Fageyinbo, Muyiwa Samuel</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>20130826</creationdate><title>Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract</title><author>Sowemimo, Abimbola ; Samuel, Femi ; Fageyinbo, Muyiwa Samuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-5a2075a5b9fc51574414512bb9f017919c6a4fb10768f07ed8d75ba5204466bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Anti-Inflammatory Agents - toxicity</topic><topic>Bignoniaceae</topic><topic>Bignoniaceae - chemistry</topic><topic>Bignoniaceae - growth & development</topic><topic>Carrageenan-induced paw oedema</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>edema</topic><topic>Edema - drug therapy</topic><topic>Edema - immunology</topic><topic>Edema - pathology</topic><topic>Ethanol - chemistry</topic><topic>Ethnopharmacology</topic><topic>Female</topic><topic>formalin</topic><topic>histamine</topic><topic>Histamine-induced paw oedema</topic><topic>inflammation</topic><topic>leaf extracts</topic><topic>leaves</topic><topic>Male</topic><topic>Markhamia tomentosa</topic><topic>Medicine, African Traditional</topic><topic>Mice</topic><topic>Nigeria</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Extracts - toxicity</topic><topic>Plant Leaves - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>rheumatoid arthritis</topic><topic>Serotonin-induced paw oedema</topic><topic>Toxicity Tests, Acute</topic><topic>Xylene-induced paw oedema</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sowemimo, Abimbola</creatorcontrib><creatorcontrib>Samuel, Femi</creatorcontrib><creatorcontrib>Fageyinbo, Muyiwa Samuel</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sowemimo, Abimbola</au><au>Samuel, Femi</au><au>Fageyinbo, Muyiwa Samuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2013-08-26</date><risdate>2013</risdate><volume>149</volume><issue>1</issue><spage>191</spage><epage>194</epage><pages>191-194</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>The leaves of Markhamia tomentosa (Benth.) K. Schum (Bignoniaceae) are used traditionally for the treatment of oedema and rheumatoid arthritis in Nigeria.
The aim of the work was to investigate the anti-inflammatory activity of the ethanolic leaf extract of Markhamia tomentosa.
The extract was screened using the carrageenan-induced paw oedema in rats, xylene-induced oedema in mice and the formalin-induced oedema in mice at 50, 100, 200mg/kg doses p.o respectively. The mechanism by which the extract mediated the anti-inflammatory activity was assessed using the histamine-induced rat paw oedema and serotonin-induced rat paw oedema at the highest dose (200mg/kg).
The results showed that the extract produced a significant dose-dependent inhibition in carrageenan-induced, xylene-induced and the formalin tests. The extract exerted a significant inhibition of 54.55% (P<0.0001) and 42.11% (P<0.01) at 90min in the histamine-induced and serotonin-induced rat paw oedema models respectively.
These findings suggest that the ethanolic leaf extract of Markhamia tomentosa possesses anti-inflammatory activity possibly mediated by histamine. The results justify the use of the plant in the preparation of ethno medicines used in the treatment of ailments associated with inflammation.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23792584</pmid><doi>10.1016/j.jep.2013.06.020</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2013-08, Vol.149 (1), p.191-194 |
| issn | 0378-8741 1872-7573 |
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| subjects | Animals anti-inflammatory activity Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents - toxicity Bignoniaceae Bignoniaceae - chemistry Bignoniaceae - growth & development Carrageenan-induced paw oedema Disease Models, Animal Dose-Response Relationship, Drug edema Edema - drug therapy Edema - immunology Edema - pathology Ethanol - chemistry Ethnopharmacology Female formalin histamine Histamine-induced paw oedema inflammation leaf extracts leaves Male Markhamia tomentosa Medicine, African Traditional Mice Nigeria Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Extracts - toxicity Plant Leaves - chemistry Rats Rats, Wistar rheumatoid arthritis Serotonin-induced paw oedema Toxicity Tests, Acute Xylene-induced paw oedema |
| title | Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract |
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