Association study of common variations of FBN1 gene and essential hypertension in Han Chinese population

• Published in: Molecular biology reports 2014, Vol.41 (4), p.2257-2264
• Main Authors: Chen, Jinfeng, Yang, Song, Zhao, Xianghai, Shen, Jiahui, Wang, Hairu, Chen, Yanchun, Ji, Yanni, Wang, Wen, Zhou, Wei, Wang, Xuecai, Tang, Junming, Lu, Xiangfeng, Chen, Shufeng, Wang, Laiyuan, Li, Hongfan, Shen, Chong, Zhao, Yanping
• Format: Article
• Language: English
• Subjects: Aged; Alleles; Animal Anatomy; Animal Biochemistry; Asian Continental Ancestry Group - genetics; Biomedical and Life Sciences; blood pressure; Blood Pressure - genetics; Case-Control Studies; China; Essential Hypertension; Female; Fibrillin-1; Fibrillins; Gene Frequency; genes; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Variation; Genotype; Genotype & phenotype; Haplotypes; Histology; Humans; Hypertension; Hypertension - diagnosis; Hypertension - genetics; Life Sciences; Male; Microfilament Proteins - genetics; Middle Aged; Molecular biology; Morphology; Odds Ratio; patients; Polymorphism, Single Nucleotide; Population genetics; prospective studies; Quantitative Trait, Heritable; regression analysis; reserpine; single nucleotide polymorphism; transforming growth factor beta 1; Transforming Growth Factor beta1 - blood
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-014-3078-9

Fibrillin-1 (FBN1) was reported to have impact on the physiological arterial stiffness and vascular remodeling with hypertension of recent years. In the previous study we reported the association of four functional single nucleotide polymorphisms (SNPs) of FBN1 gene and hypertension. Here, we further investigate the association of four tagging SNPs (tagSNPs) which covered remain genetic variation blocks of FBN1 gene with hypertension, blood pressure and efficacy of antihypertensive in a South Han Chinese population. A case–control study including 2,012 hypertension cases and 2,116 controls age- and sex-matched controls was conducted from a community-based population and four candidate tagSNPs of the FBN1 gene were genotyped. Association analysis by multiple logistic regression was conducted for allele, genotype and haplotype and hypertension, blood pressure trait and control status with antihypertensive. General linear model was applied to compare blood pressure levels between genotypes. The association of rs17361868 and hypertension was statistically significant and that was further observed in female, ≥55 years, non-smoking and non-drinking populations (P < 0.05). Significant association of rs668842, rs11635140 and hypertension were observed in