association between the Lys751Gln polymorphism in the XPD gene and the risk of bladder cancer

The Lys751Gln polymorphism in the XPD gene have been suggested as a risk factor for bladder cancer, however the results were inconclusive. The aim of the current study is to assess the association by meta-analysis. A total of 15 case–control studies concerning the association between the XPD Lys751G...

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Bibliographic Details
Published in:Molecular biology reports 2014, Vol.41 (4), p.2629-2634
Main Authors: Xiong, Tianyuan, Yang, Jiqiao, Wang, Haichuan, Wu, Fanyi, Liu, Yang, Xu, Rui, Lv, Zi, Xue, Pei, Cao, Wen, Zhang, Yonggang
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Animal Anatomy
Animal Biochemistry
Asians
Biomedical and Life Sciences
bladder
Bladder cancer
Case-Control Studies
Codon
DNA-Binding Proteins - genetics
Endonucleases - genetics
Ethnic Groups - genetics
genes
Genetic Association Studies
Genetic Predisposition to Disease
Genomics
Histology
Humans
Life Sciences
Meta-analysis
Morphology
Nuclear Proteins - genetics
Odds Ratio
Polymorphism
Polymorphism, Genetic
Publication Bias
Risk
Risk factors
Transcription Factors - genetics
Urinary Bladder Neoplasms - genetics
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Summary:The Lys751Gln polymorphism in the XPD gene have been suggested as a risk factor for bladder cancer, however the results were inconclusive. The aim of the current study is to assess the association by meta-analysis. A total of 15 case–control studies concerning the association between the XPD Lys751Gln polymorphism and bladder cancer risk were included in the meta-analysis. The results suggested that the Lys751Gln polymorphism was not associated with an increased risk of bladder cancer in the dominant model (OR = 1.03, 95 % CI 0.95–1.11, P = 0.53 for Lys/Gln+Gln/Gln vs. Lys/Lys) in overall analysis. In the subgroup analysis by ethnicity, no significant association was found in Caucasians or Asians. Other comparatives suggested a slight significant association between the polymorphism with the risk of bladder cancer in the recessive comparative (OR = 1.14, 95 % CI 1.02–1.29, P = 0.03). The current meta-analysis indicated that the Lys751Gln polymorphism in the XPD gene might be a risk factor for bladder cancer. In the future, more large-scale case–control studies are needed to validate our results.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-014-3121-x