Role of beta‐defensin 2 and interleukin‐4 receptor as stroke outcome biomarkers

Acute ischemic stroke is a complex disease with huge interindividual evolution variability that makes challenging the prediction of an adverse outcome. Our aim was to study the association of bloodstream signatures to early neurological outcome after stroke, by combining a subpooling of samples stra...

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Bibliographic Details
Published in:Journal of neurochemistry 2014-05, Vol.129 (3), p.463-472
Main Authors: García‐Berrocoso, Teresa, Giralt, Dolors, Bustamante, Alejandro, Llombart, Victor, Rubiera, Marta, Penalba, Anna, Boada, Cristina, Espadaler, Marc, Molina, Carlos, Montaner, Joan
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Area Under Curve
beta-Defensins - blood
Biomarkers
Biomarkers - blood
cerebral ischemia
Cytokines
Female
Humans
immune response
Male
Neurochemistry
outcome
prognosis
Proteins
Receptors, Interleukin-4 - blood
Recovery of Function
ROC Curve
Sensitivity and Specificity
Stroke
Stroke - blood
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Summary:Acute ischemic stroke is a complex disease with huge interindividual evolution variability that makes challenging the prediction of an adverse outcome. Our aim was to study the association of bloodstream signatures to early neurological outcome after stroke, by combining a subpooling of samples strategy with protein array discovery approach. Plasma samples from 36 acute stroke patients (
ISSN:0022-3042
1471-4159
DOI:10.1111/jnc.12649