Anti-parkinsonism, hypoglycemic and anti-microbial activities of new poly fused ring heterocyclic candidates

• Published in: International journal of biological macromolecules 2013-06, Vol.57, p.165-173
• Main Authors: Al-Harbi, Naif O., Bahashwan, Saleh A., Fayed, Ahmed A., Aboonq, Moutasem S., Amr, Abd El-Galil E.
• Format: Article
• Language: English
• Subjects: Animals; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; anti-infective properties; Anti-parkinsonism; Antiparkinson Agents - chemical synthesis; Antiparkinson Agents - chemistry; Antiparkinson Agents - pharmacology; Aspergillus fumigatus - growth & development; Bacteria - growth & development; Candida albicans - growth & development; chemical reactions; Heterocyclic candidates; Heterocyclic Compounds, 2-Ring - chemical synthesis; Heterocyclic Compounds, 2-Ring - chemistry; Heterocyclic Compounds, 2-Ring - pharmacology; Hypoglycemic Agents - chemical synthesis; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Hypoglycemic and anti-microbial activities; medicinal properties; Mice; Parkinson Disease, Secondary - chemically induced; Parkinson Disease, Secondary - drug therapy; Poly ring systems; pyrimidines; spectral analysis
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2013.03.019

A new series of poly fused pyrazolothienopyrimidine derivatives (2–14) were synthesized and their anti-parkinsonism, hypoglycemic and anti-microbial activities were evaluated. Some of the newly synthesized compounds exhibited better pharmacological and biological activities than the reference controls with low concentrations. The structures of newly synthesized compounds were confirmed by chemical, elemental and spectroscopic evidences. The detailed synthesis, spectroscopic data, and pharmacological activities were reported.