Antityrosinase and antimicrobial activities of furfuryl alcohol, furfural and furoic acid

The inhibitory kinetics of furfuryl alcohol, furfural and furoic acid on mushroom tyrosinase have been investigated. The results showed that these furan compounds were reversible inhibitors of the enzyme. Furthermore, furfuryl alcohol and furfural were found to be mixed-type inhibitors while furoic...

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Bibliographic Details
Published in:International journal of biological macromolecules 2013-06, Vol.57, p.151-155
Main Authors: Chai, Wei-Ming, Liu, Xuan, Hu, Yong-Hua, Feng, Hui-Ling, Jia, Yu-Long, Guo, Yun-Ji, Zhou, Han-Tao, Chen, Qing-Xi
Format: Article
Language:English
Subjects:
alcohols
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
anti-infective properties
Antimicrobial activities
Antityrosinase activities
Bacillus subtilis
Bacillus subtilis - growth & development
bacteria
enzyme inhibition
enzyme inhibitors
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Fungal Proteins - antagonists & inhibitors
Fungal Proteins - chemistry
Furaldehyde - chemistry
Furaldehyde - pharmacology
Furans - chemistry
Furans - pharmacology
Furfural
Furfuryl alcohol
Furoic acid
Inhibitory kinetics
minimum inhibitory concentration
Monophenol Monooxygenase - antagonists & inhibitors
Monophenol Monooxygenase - chemistry
mushrooms
Salmonella
Salmonella - growth & development
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Summary:The inhibitory kinetics of furfuryl alcohol, furfural and furoic acid on mushroom tyrosinase have been investigated. The results showed that these furan compounds were reversible inhibitors of the enzyme. Furthermore, furfuryl alcohol and furfural were found to be mixed-type inhibitors while furoic acid is uncompetitive inhibitor. The inhibition constants have been confirmed and the order of the inhibiting ability was furfural>furoic acid>furfuryl alcohol. They indicate that the functional groups on the furan ring play a crucial role in the inhibition on the enzyme. In addition, it was also found that these furan compounds could inhibit the proliferation of Salmonella bacteria and Bacillus subtilis to different extents. The minimum inhibitory concentration (MIC) values of furfuryl alcohol, furfural and furoic acid against B. subtilis and S. bacteria were 0.115, 0.027, 0.015 and 0.115, 0.029, 0.009μM, respectively. The minimum bactericidal concentration (MBC) values of that were 0.115, 0.027, 0.015 and 0.231, 0.121, 0.030μM, respectively.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2013.02.019