Cold adaptation improves the growth of seasonal influenza B vaccine viruses

Highlights • Unpredictable yields of influenza B vaccine viruses remain a major concern for the manufacturers. • The variable growth of influenza B vaccine viruses in eggs is exemplified in this paper. • A process of cold adaptation enhancing the growth of influenza B vaccine viruses is demonstrated...

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Bibliographic Details
Published in:Vaccine 2014-05, Vol.32 (21), p.2474-2479
Main Authors: Kim, Hyunsuh, Schoofs, Peter, Anderson, David A, Tannock, Gregory A, Rockman, Steven P
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Allergy and Immunology
Animals
Antigens
Applied microbiology
Biological and medical sciences
Cell culture
Chickens
Cold adaptation
Cold Temperature
Dogs
Eggs
Fundamental and applied biological sciences. Psychology
Growth
Hemagglutination Inhibition Tests
Hemagglutinin Glycoproteins, Influenza Virus - isolation & purification
Immunization
Inactivated vaccine
Influenza
Influenza B virus
Influenza B virus - genetics
Influenza B virus - growth & development
Influenza Vaccines
Madin Darby Canine Kidney Cells
Microbiology
Miscellaneous
Ovum - virology
Reassortant Viruses - genetics
Reassortant Viruses - growth & development
Serial Passage
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Virology
Virus Cultivation
Viruses
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Summary:Highlights • Unpredictable yields of influenza B vaccine viruses remain a major concern for the manufacturers. • The variable growth of influenza B vaccine viruses in eggs is exemplified in this paper. • A process of cold adaptation enhancing the growth of influenza B vaccine viruses is demonstrated in this paper. • Novel influenza B donor viruses were developed for the preparation of inactivated vaccines in this paper.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.02.079