Molecular analysis of α-synuclein gene in Parkinson's disease in North Karnataka, India

Parkinson's disease (PD) is a disabling neurological disorder characterized by progressive degeneration of dopaminergic neurons. Mutations analysis within the α-synuclein gene (SNCA) on chromosome 4 has been reported in the last decade. To elucidate the possible role of SNCA gene in the pathoge...

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Bibliographic Details
Published in:Neurology India 2014-03, Vol.62 (2), p.149-152
Main Authors: Kadakol, G S, Kulkarni, S S, Wali, G M, Gai, Pramod B
Format: Article
Language:English
Subjects:
Adult
alpha-Synuclein - genetics
DNA Mutational Analysis - methods
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
India
Male
Middle Aged
Mutation - genetics
Parkinson Disease - diagnosis
Parkinson Disease - genetics
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Summary:Parkinson's disease (PD) is a disabling neurological disorder characterized by progressive degeneration of dopaminergic neurons. Mutations analysis within the α-synuclein gene (SNCA) on chromosome 4 has been reported in the last decade. To elucidate the possible role of SNCA gene in the pathogenesis of PD in Indian population specifically in north Karnataka. The study subjects included 100 clinically diagnosed PD patients and 100 ethnically matched healthy controls. Isolated deoxyribonucleic acid (DNA) samples from both were subjected to exon-specific polymerase chain reaction (PCR) amplification and amplicons were subjected to capillary-based direct DNA sequencing. No mutations were observed in SNCA gene of PD samples in comparison with control samples. These findings support the hypothesis that the SNCA gene mutations might be population specific and may not be playing role in causing PD in all the populations.
ISSN:0028-3886
DOI:10.4103/0028-3886.132338