New diagnostic possibilities in systemic neonatal infections: metabolomics

ABSTRACT Systemic neonatal infection is a serious complication in preterm and term infants and is defined as a complex clinical syndrome caused by bacteria, fungi and virus. Sepsis remains among the leading causes of death in both developed and underdeveloped countries above all in the neonatal peri...

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Bibliographic Details
Published in:Early human development 2014-03, Vol.90, p.S19-S21
Main Authors: Dessì, Angelica, Corsello, Giovanni, Stronati, Mauro, Gazzolo, Diego, Caboni, Pierluigi, Carboni, Roberta, Fanos, Vassilios
Format: Article
Language:English
Subjects:
Advanced Basic Science
Biomarkers - metabolism
Humans
Infant, Newborn
Metabolomics
Neonatal and Perinatal Medicine
Neonatal infections
Newborn
Sepsis
Sepsis - diagnosis
Sepsis - metabolism
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Summary:ABSTRACT Systemic neonatal infection is a serious complication in preterm and term infants and is defined as a complex clinical syndrome caused by bacteria, fungi and virus. Sepsis remains among the leading causes of death in both developed and underdeveloped countries above all in the neonatal period. Earlier diagnosis may offer the ability to initiate treatment to prevent adverse outcomes. There have been many studies on various diagnostic haematological markers like acute phase reactants, C-reactive protein, procalcitonin, interleukins and presepsin. However, there is still no single test that satisfies the criteria as being the ideal marker for the early diagnosis of neonatal sepsis. In this regard, metabolomic analysis seems to be a promising method for determining metabolic variations correlated with systemic neonatal infections.
ISSN:0378-3782
1872-6232
DOI:10.1016/S0378-3782(14)70007-6