Comparative Analysis of Early and Delayed Cardioprotective and Antiarrhythmic Efficacy of Hypoxic Preconditioning

Hypoxic preconditioning produces an infarct-limiting effect both in the early and delayed periods. The increase in heart resistance to ischemia–repefusion was more pronounced after early preconditioning. Hypoxic preconditioning did not change heart resistance to the arrhythmogenic effect of coronary...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-04, Vol.156 (6), p.746-749
Main Authors: Maslov, L. N., Lishmanov, Yu. B., Krylatov, A. V., Sementsov, A. S., Portnichenko, A. G., Podoksenov, Yu. K., Khaliulin, I. G.
Format: Article
Language:English
Subjects:
Animals
Anti-Arrhythmia Agents - therapeutic use
Anti-arrhythmia drugs
Antiarrhythmics
Arrhythmias, Cardiac - pathology
Biomedical and Life Sciences
Biomedicine
Cardiotonic Agents - therapeutic use
Cell Biology
Coronary Occlusion - pathology
Heart
Hypoxia - physiopathology
Internal Medicine
Ischemia
Ischemic Preconditioning, Myocardial - methods
Laboratory Medicine
Male
Myocardial Infarction - prevention & control
Myocardial Reperfusion Injury - prevention & control
Pathology
Rats
Rats, Wistar
Reperfusion
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Summary:Hypoxic preconditioning produces an infarct-limiting effect both in the early and delayed periods. The increase in heart resistance to ischemia–repefusion was more pronounced after early preconditioning. Hypoxic preconditioning did not change heart resistance to the arrhythmogenic effect of coronary occlusion and reperfusion.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2439-7