Sleep state-specific neuronal activity in rat dorsal lateral geniculate nucleus is not altered by local serotonin and norepinephrine depletion

The relay cells in dorsal lateral geniculate nucleus (dLGN) represent one among many populations of neurons throughout the neuraxis that display systematic alteration of spontaneous rate and pattern of discharge concurrent with change in state of arousal. Both noradrenergic (NE) and serotonergic (5-...

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Bibliographic Details
Published in:Experimental brain research 1989, Vol.74 (2), p.402-410
Main Authors: MARKS, G. A, SPECIALE, S. G, ROFFWARG, H. P
Format: Article
Language:English
Subjects:
5,7-Dihydroxytryptamine
Animals
Biological and medical sciences
Electroencephalography
Fundamental and applied biological sciences. Psychology
Geniculate Bodies - drug effects
Geniculate Bodies - metabolism
Geniculate Bodies - physiology
Hydroxydopamines
Locus Coeruleus - physiology
Male
Norepinephrine - metabolism
Norepinephrine - physiology
Ocular Physiological Phenomena
Oxidopamine
Raphe Nuclei - physiology
Rats
Serotonin - metabolism
Serotonin - physiology
Sleep Stages - physiology
Sleep. Vigilance
Vertebrates: nervous system and sense organs
Citations: Items that cite this one
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Summary:The relay cells in dorsal lateral geniculate nucleus (dLGN) represent one among many populations of neurons throughout the neuraxis that display systematic alteration of spontaneous rate and pattern of discharge concurrent with change in state of arousal. Both noradrenergic (NE) and serotonergic (5-HT) systems innervate dLGN and are implicated in sleep-wake control mechanisms. Our study was designed to test the influence of these systems upon sleep state-related multiple unit activity in the dLGN. Two monoamine neurotoxins, 5,7-dihydroxytryptamine and 6-hydroxydopamine, were injected locally into dLGN to destroy NE and 5HT afferents individually and in combination. In three separate treatment groups, mean monoamine concentrations in dLGN were reduced in relation to the contralateral, vehicle-injected, control dLGN to: 1) NE-17%, 5HT-14%; 2) NE-46%, 5HT-28%, and 3) NE-6%, 5HT-77%. In no case was chronic sleep state-related cell activity in dLGN significantly altered. We conclude that afferent monoaminergic inputs are not critically related to the mechanisms underlying normative shifts in sleep state-related neuronal activity in dLGN.
ISSN:0014-4819
1432-1106
DOI:10.1007/BF00248874