5-HT sub(1) agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis

An intracerebral perfusion method, brain microdialysis, was used to assess changes of 5-hydroxytryptamine (5-HT) release in the ventral hippocampus of the chloral hydrate-anaesthetized rat in response to systemic administration of a variety of 5-HT sub(1) receptor agonists. The data are direct bioch...

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Bibliographic Details
Published in:British journal of pharmacology 1989-01, Vol.96 (2), p.283-290
Main Authors: Sharp, T, Bramwell, SR, Grahame-Smith, D G
Format: Article
Language:English
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Summary:An intracerebral perfusion method, brain microdialysis, was used to assess changes of 5-hydroxytryptamine (5-HT) release in the ventral hippocampus of the chloral hydrate-anaesthetized rat in response to systemic administration of a variety of 5-HT sub(1) receptor agonists. The data are direct biochemical evidence that systemically administered putative 5-HT sub(1A) and 5-HT sub(1B) agonists markedly inhibit 5-HT release in rat ventral hippocampus in vivo.
ISSN:0007-1188