Arylboronate Ester Based Diazeniumdiolates (BORO/NO), a Class of Hydrogen Peroxide Inducible Nitric Oxide (NO) Donors

Here, we report the design, synthesis, and evaluation of arylboronate ester based diazeniumdiolates (BORO/NO), a class of nitric oxide (NO) donors activated by hydrogen peroxide (H2O2), a reactive oxygen species (ROS), to generate NO. We provide evidence for the NO donors’ ability to permeate bacter...

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Bibliographic Details
Published in:Organic letters 2014-05, Vol.16 (10), p.2610-2613
Main Authors: Dharmaraja, Allimuthu T, Ravikumar, Govindan, Chakrapani, Harinath
Format: Article
Language:English
Subjects:
Azo Compounds - chemistry
Boron Compounds - chemistry
Hydrogen Peroxide - chemistry
Molecular Structure
Nitric Oxide - chemical synthesis
Nitric Oxide - chemistry
Nitric Oxide Donors - chemical synthesis
Nitric Oxide Donors - chemistry
Reactive Oxygen Species - chemistry
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Summary:Here, we report the design, synthesis, and evaluation of arylboronate ester based diazeniumdiolates (BORO/NO), a class of nitric oxide (NO) donors activated by hydrogen peroxide (H2O2), a reactive oxygen species (ROS), to generate NO. We provide evidence for the NO donors’ ability to permeate bacteria to produce NO when exposed to H2O2 supporting possible applications for BORO/NO to study molecular mechanisms of NO generation in response to elevated ROS.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol5010643