HTS assays for developing the molecular pharmacology of ion channels

Highlights • Improved ion channel assay technologies have become available over the past ten years. • Fluorescent assay methods are most common in ion channel HTS. • High throughput electrophysiology may become alternative approach for focused libraries. • Improvements in sensor technologies will dr...

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Bibliographic Details
Published in:Current opinion in pharmacology 2014-04, Vol.15, p.91-96
Main Author: McManus, Owen B
Format: Article
Language:English
Subjects:
Drug Discovery - methods
High-Throughput Screening Assays - methods
Internal Medicine
Ion Channels - chemistry
Ion Channels - drug effects
Ion Channels - metabolism
Medical Education
Molecular Targeted Therapy
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Summary:Highlights • Improved ion channel assay technologies have become available over the past ten years. • Fluorescent assay methods are most common in ion channel HTS. • High throughput electrophysiology may become alternative approach for focused libraries. • Improvements in sensor technologies will drive advances in ion channel discovery.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2014.01.004