Tumor/stromal caveolin-1 expression patterns in pleural mesothelioma define a subgroup of the epithelial histotype with poorer prognosis

Malignant pleural mesothelioma (MPM) is a highly aggressive disease for which new prognostic biomarkers need to be identified. Caveolin-1 (CAV1), the most important member of caveolae, has been described as deregulated in MPM at the genomic level, but detailed histologic information on its distribut...

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Bibliographic Details
Published in:American journal of clinical pathology 2014-06, Vol.141 (6), p.816-827
Main Authors: Righi, Luisella, Cavallo, Maria Cristina, Gatti, Gaia, Monica, Valentina, Rapa, Ida, Busso, Simone, Albera, Carlo, Volante, Marco, Scagliotti, Giorgio V, Papotti, Mauro
Format: Article
Language:English
Subjects:
Aged
Caveolin 1 - metabolism
Cell Line, Tumor
Female
Humans
Immunohistochemistry
Lung Neoplasms - metabolism
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Male
Mesothelioma - metabolism
Mesothelioma - mortality
Mesothelioma - pathology
Mesothelioma, Malignant
Middle Aged
Pleural Neoplasms - metabolism
Pleural Neoplasms - mortality
Pleural Neoplasms - pathology
Prognosis
Stromal Cells - metabolism
Stromal Cells - pathology
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Summary:Malignant pleural mesothelioma (MPM) is a highly aggressive disease for which new prognostic biomarkers need to be identified. Caveolin-1 (CAV1), the most important member of caveolae, has been described as deregulated in MPM at the genomic level, but detailed histologic information on its distribution and prognostic role is still lacking. A series of 131 MPMs (91 epithelial, 17 biphasic, and 23 sarcomatous histotype) were investigated for CAV1 expression with immunohistochemistry and correlated with clinical-pathologic variables and outcome. CAV1 was detected in neoplastic cells of 70 (77%) of 91 epithelial, 17 (100%) of 17 biphasic, and 23 (100%) of 23 sarcomatous MPMs. Furthermore, in the epithelial group, CAV1 expression in spindle-shaped stromal cells was detected in 61 (67%) of 91 cases. The presence of stromal CAV1 expression was associated with a worse patient outcome. In MPM, CAV1 is differentially expressed according to low- to high-grade histotypes. Furthermore, in the MPM epithelial group, additional stromal CAV1 expression is associated with a worse prognosis.
ISSN:0002-9173
1943-7722
DOI:10.1309/AJCP0F6WYBXGVDHX