Crystal-storing histiocytosis associated with marginal-zone lymphoma

We report a rare case of crystal-storing histiocytosis (CSH) associated with marginal-zone lymphoma. A 91-year-old woman with a history of breast cancer presented with masses of the posterior neck, right breast, and left upper arm. An enlarging mass of the neck was removed and was histologically dia...

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Bibliographic Details
Published in:Japanese journal of radiology 2014-05, Vol.32 (5), p.296-301
Main Authors: Tahara, Keiichiro, Miyajima, Kimitaka, Ono, Minoru, Sugio, Yasuhiro, Yamamoto, Ichiro, Tamiya, Sadafumi
Format: Article
Language:English
Subjects:
Aged, 80 and over
Biopsy, Fine-Needle
Breast Diseases - diagnostic imaging
Breast Diseases - pathology
Case Report
Cytological Techniques
Diagnosis, Differential
Female
Head and Neck Neoplasms - diagnostic imaging
Head and Neck Neoplasms - pathology
Histiocytosis - diagnostic imaging
Histiocytosis - pathology
Humans
Imaging
Lymphoma, B-Cell, Marginal Zone - diagnostic imaging
Lymphoma, B-Cell, Marginal Zone - pathology
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Radiology
Radiotherapy
Ultrasonography, Mammary
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Summary:We report a rare case of crystal-storing histiocytosis (CSH) associated with marginal-zone lymphoma. A 91-year-old woman with a history of breast cancer presented with masses of the posterior neck, right breast, and left upper arm. An enlarging mass of the neck was removed and was histologically diagnosed as CSH, associated with marginal-zone lymphoma. Masses in the breast and upper arm were evaluated by needle biopsy and revealed as CSH. CSH is a rare condition characterized by the intrahistiocytic accumulation of crystallized immunoglobulins, and is associated with disorders in which monoclonal immunoglobulins are expressed. To the best of our knowledge, there are few previous descriptions of CSH which include the imaging features of this disease. In the present case, the masses showed hypoechogenicity with internal patchy hyperechoic areas on ultrasonography, and an iso-signal to slight hyperintensity compared with muscle on T2-weighted magnetic resonance imaging. We report the imaging findings in CSH and discuss their diagnostic implications.
ISSN:1867-1071
1867-108X
DOI:10.1007/s11604-014-0302-4