Effect of variation of ABCB1 and GSTP1 on osteosarcoma survival after chemotherapy

We conducted a comprehensive study to investigate the role of genes involved in metabolic and transport pathways in response to chemotherapy and clinical outcome of osteosarcoma patients. Genotyping of seven gene polymorphisms was performed on a 384-well plate format on the Sequenom MassARRAY platfo...

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Bibliographic Details
Published in:Genetics and molecular research 2014-04, Vol.13 (2), p.3186-3192
Main Authors: Li, J Z, Tian, Z Q, Jiang, S N, Feng, T
Format: Article
Language:English
Subjects:
Adolescent
Adult
ATP Binding Cassette Transporter, Sub-Family B - genetics
Biomarkers, Pharmacological
Bone Neoplasms - drug therapy
Bone Neoplasms - genetics
Bone Neoplasms - pathology
Child
Disease-Free Survival
Doxorubicin - administration & dosage
Female
Glutathione S-Transferase pi - genetics
Humans
Male
Metabolic Detoxication, Phase II - genetics
Middle Aged
Osteosarcoma - drug therapy
Osteosarcoma - genetics
Osteosarcoma - pathology
Polymorphism, Single Nucleotide
Prognosis
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Summary:We conducted a comprehensive study to investigate the role of genes involved in metabolic and transport pathways in response to chemotherapy and clinical outcome of osteosarcoma patients. Genotyping of seven gene polymorphisms was performed on a 384-well plate format on the Sequenom MassARRAY platform in 162 patients with osteosarcoma. We studied the correlation of the seven gene polymorphisms with response to chemotherapy and clinical outcome of patients. Individuals with the ABCB1 TT genotype had a higher probability of responding poorly to chemotherapy, indicated by an odds ratio (OR) of 2.64 (95%CI=1.04-6.83). Similarly, the genotype of GSTP1 GG was significantly associated with improved responses to chemotherapy, indicated by an OR of 3.33 (95%CI=1.26-8.99). The ABCB1 TT and GSTP1 GG genotypes were significantly associated with a shorter overall survival (OS). Our study found that two gene polymorphisms in two transporter genes and one Phase II metabolism enzymes are associated with response to chemotherapy and OS in osteosarcoma patients, suggesting the potential of the two gene polymorphisms as prognostic biomarkers for osteosarcoma.
ISSN:1676-5680
1676-5680
DOI:10.4238/2014.April.25.3